(kIP3deg * (IP3_Cyt - IP3_basal))
0.16
0.16
Rate_IP3deg
100.0
(kf_IP3PH * KdIP3PH)
2.0
kf_IP3PH
kr_IP3PH
(((kf_IP3PH * IP3_Cyt) * PH_GFP_Cyt) - (kr_IP3PH * IP3_PHGFP_Cyt))
200.0
(kf_PIP2PH * KdPIP2PH)
2.0
kf_PIP2PH
kr_PIP2PH
(((kf_PIP2PH * PH_GFP_Cyt) * PIP2_PM) - (kr_PIP2PH * PIP2_PHGFP_PM))
((Rate_PIP2Synbasal + Rate_PIP2SynStim) * PIP_PM)
((kBasalSynPIP2 * 0.581 * ( - 1.0 + exp(((PIP2_basal - PIP2_PM) / PIP2_basal)))) * (PIP2_PM < PIP2_basal))
(kStimSynPIP2 * exp( - ((t - tauPIP2syn) / PIP2syndecay)) * (t > tauPIP2syn))
0.045
1072.0
0.01
0.05
10.0
Rate_PIP2Syn
((Ratebasal_PIPsyn + Ratestim_PIPsyn) * PI_PM)
((kBasalSynPIP * 0.581 * ( - 1.0 + exp(((PIP_basal - PIP_PM) / PIP_basal)))) * (PIP_PM < PIP_basal))
(kStimSynPIP * exp( - ((t - tauPIPsyn) / PIPsyndecay)) * (t > tauPIPsyn))
0.0015
2857.0
0.01
0.05
10.0
Rate_PIPSyn
(k_PIP2hyd * (PIP2_PM * PLC_act_PM))
1.188
Rate_PIP2_hyd
(intensity * IP3X_Cytosol * hv_Cytosol)
100000.0
J_IP3_uncaging
((KfPLCact * (PLC_PM * stim_PM * signal)) - (krPLCact * PLC_act_PM))
1000.0
((t > tau0) * exp( - ((t - tau0) / stimdecay)))
10.0
0.05
6.0
RatePLCact
(k_PIP2PHhyd * PLC_act_PM * PIP2_PHGFP_PM)
50.0
RatePIP2_PH_hyd
1.0
0.0
0.0
0.0
0.0
0.0
0.0
0.0
0.16
0.0
0.0
0.0
1200000.0
0.0
0.0
0.0
12000.0
0.0
0.0
0.0
2000.0
0.0
0.0
0.0
0.0
0.0
2.0
0.0015
0.0
0.16
100000.0
1000.0
0.0
96480.0
10.0
8314.0
0.0
2857.0
10.0
0.0
0.01
2000.0
1200000.0
1.188
1.0
0.263
0.16
1200000.0
0.16
0.0
12000.0
0.1
2.0
6.0
200.0
0.0
0.8
0.0
0.01
(1.0 / 602.0)
1.0
10.0
0.05
1.0
0.05
0.0
0.0
1072.0
300.0
100.0
0.045
12000.0
1000.0
0.16
50.0
0.05
(kf_PIP2PH * KdPIP2PH)
(((kf_PIP2PH * PH_GFP_Cyt) * PIP2_PM) - (kr_PIP2PH * PIP2_PHGFP_PM))
((t > tau0) * exp( - ((t - tau0) / stimdecay)))
(kStimSynPIP2 * exp( - ((t - tauPIP2syn) / PIP2syndecay)) * (t > tauPIP2syn))
((PLC_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PLC_act_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))
((K_PLC_PM_total - (PLC_act_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))
((KfPLCact * (PLC_PM * stim_PM * signal)) - (krPLCact * PLC_act_PM))
((kBasalSynPIP * 0.581 * ( - 1.0 + exp(((PIP_basal - PIP_PM) / PIP_basal)))) * (PIP_PM < PIP_basal))
(kStimSynPIP * exp( - ((t - tauPIPsyn) / PIPsyndecay)) * (t > tauPIPsyn))
((Ratebasal_PIPsyn + Ratestim_PIPsyn) * PI_PM)
(k_PIP2hyd * (PIP2_PM * PLC_act_PM))
(hv_Cytosol_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol)
(K_hv_Cytosol_total / ((1.0 - VolFract_Nucleus) * VolFract_Cytosol))
((kBasalSynPIP2 * 0.581 * ( - 1.0 + exp(((PIP2_basal - PIP2_PM) / PIP2_basal)))) * (PIP2_PM < PIP2_basal))
((Rate_PIP2Synbasal + Rate_PIP2SynStim) * PIP_PM)
SurfToVol_NM
(kf_IP3PH * KdIP3PH)
(((kf_IP3PH * IP3_Cyt) * PH_GFP_Cyt) - (kr_IP3PH * IP3_PHGFP_Cyt))
(SurfToVol_NM * VolFract_Nucleus / (1.0 - VolFract_Nucleus))
(SurfToVol_PM / (1.0 - VolFract_Nucleus))
0.0
(kIP3deg * (IP3_Cyt - IP3_basal))
(SurfToVol_PM * VolFract_Cytosol / (1.0 - VolFract_Cytosol))
(intensity * IP3X_Cytosol * hv_Cytosol)
(k_PIP2PHhyd * PLC_act_PM * PIP2_PHGFP_PM)
0.0
IP3_PHGFP_Cyt_init
- J_IP3_uncaging
IP3X_Cytosol_init
(J_PIP2_PH - RatePIP2_PH_hyd)
PIP2_PHGFP_PM_init
( - Rate_PIP2Syn + Rate_PIPSyn)
PIP_PM_init
(Rate_PIP2_hyd + RatePIP2_PH_hyd)
DAG_PM_init
RatePLCact
PLC_act_PM_init
J_IP3_PHGFP
4000.0
100000.0
100.0
300.0
0.16
0.16
2857.0
0.0
0.01
0.05
0.05
0.05
10.0
(1.0 / 602.0)
0.0015
0.8
0.0
142857.0
2.30769
0.0
0.0
96480.0
10.0
0.01
1.0
1.188
0.045
2000.0
0.0
142857.0
8314.0
1000.0
4000.0
100.0
0.0
0.1
6.0
4617.4
0.16
10.0
200.0
3.6923
0.0
2.30769
0.1
2.0
4000.0
50.0
0.16
0.263
Total PIP2 + both complexes = 12,000molec/um2
2.30769
0.0
3.6923
0.0
1.0
0.0
1.01446
0.0
0.16
0.0
4617.4
0.0
142857.0
0.0
1.0
0.0
4000.0
0.0
2857.0
0.0
2000.0
0.0
100.0
0.0
0.0
0.0
2.0
100.0
0.16
100000.0
1000.0
1.0
96480.0
8314.0
1.0
3.6923
2000.0
142857.0
2.30769
1.0
0.263
0.16
0.16
2857.0
4000.0
0.1
2.0
6.0
200.0
0.0
0.8
1.01446
(1.0 / 602.0)
10.0
0.05
1.0
1.0
4617.4
300.0
100.0
1000.0
50.0
(PI_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE)
( - (DAG_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP2_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PH_GFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol) + (IP3_PHGFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol))
(((DAG_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + K_PH_GFP_Cyt_total - (IP3_PHGFP_Cyt * (1.0 - VolFract_Nucleus) * VolFract_Cytosol)) / ((1.0 - VolFract_Nucleus) * VolFract_Cytosol))
(kf_PIP2PH * KdPIP2PH)
((DAG_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PHGFP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))
(( - (DAG_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + K_PIP2_PHGFP_PM_total - (PIP2_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))
(((kf_PIP2PH * PH_GFP_Cyt) * PIP2_PM) - (kr_PIP2PH * PIP2_PHGFP_PM))
((t > tau0) * exp( - ((t - tau0) / stimdecay)))
((PLC_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PLC_act_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))
((K_PLC_PM_total - (PLC_act_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))
((KfPLCact * (PLC_PM * stim_PM * signal)) - (krPLCact * PLC_act_PM))
(PIP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE)
(K_PIP_PM_total / (SurfToVol_PM * VolFract_Cytosol * KMOLE))
SurfToVol_NM
(K_PI_PM_total / (SurfToVol_PM * VolFract_Cytosol * KMOLE))
(kf_IP3PH * KdIP3PH)
(((kf_IP3PH * IP3_Cyt) * PH_GFP_Cyt) - (kr_IP3PH * IP3_PHGFP_Cyt))
(SurfToVol_NM * VolFract_Nucleus / (1.0 - VolFract_Nucleus))
(SurfToVol_PM / (1.0 - VolFract_Nucleus))
0.0
(kIP3deg * (IP3_Cyt - IP3_basal))
(SurfToVol_PM * VolFract_Cytosol / (1.0 - VolFract_Cytosol))
(intensity * IP3X_Cytosol * hv_Cytosol)
(k_PIP2PHhyd * PLC_act_PM * PIP2_PHGFP_PM)
J_IP3_PHGFP
IP3_PHGFP_Cyt_init
- J_IP3_uncaging
IP3X_Cytosol_init
((RatePIP2_PH_hyd * Kflux_PM_Cytosol * KMOLE) + J_IP3_uncaging - Rate_IP3deg - J_IP3_PHGFP)
IP3_Cyt_init
- J_PIP2_PH
PIP2_PM_init
RatePIP2_PH_hyd
DAG_PM_init
RatePLCact
PLC_act_PM_init
0.0
4617.4
100.0
1.0
4000.0
0.12
2857.0
1.0
2000.0
0.5
0.8
1.0
2.0
0.0
3.6923
0.0
0.16
0.1
0.0
6.0
0.16
0.08
100000.0
0.0
0.0
0.1
1000.0
(1.0 / 602.0)
142857.0
10.0
10.0
2.30769
300.0
96480.0
1.01446
8314.0
0.0
(4617.4 * 3.0)
100.0
1.0
4000.0
0.12
2857.0
1.0
2000.0
0.5
0.8
1.0
2.0
0.0
(3.6923 * 3.0)
0.0
0.16
0.1
0.0
6.0
0.16
0.08
100000.0
0.0
0.0
0.1
1000.0
(1.0 / 602.0)
142857.0
10.0
10.0
(2.30769 * 3.0)
300.0
96480.0
1.01446
8314.0
0.0
(4617.4 * 0.3)
100.0
1.0
4000.0
0.12
2857.0
1.0
2000.0
0.5
0.8
1.0
2.0
0.0
(3.6923 * 0.3)
0.0
0.16
0.1
0.0
6.0
0.16
0.08
100000.0
0.0
0.0
0.1
1000.0
(1.0 / 602.0)
142857.0
10.0
10.0
(2.30769 * 0.3)
300.0
96480.0
1.01446
8314.0
0.0
4617.4
100.0
1.0
4000.0
0.12
2857.0
1.0
2000.0
0.5
0.8
1.0
2.0
0.0
3.6923
0.0
0.16
0.1
0.0
6.0
0.16
0.16
100000.0
0.0
0.0
0.1
1000.0
(1.0 / 602.0)
142857.0
10.0
10.0
2.30769
300.0
96480.0
0.0
8314.0
(copied from Average Exp Params - Comp) (copied from SS for Exp params) (copied from steady state compartment)
5.46296
0.0
0.437037
0.0
0.0
0.0
0.0
0.0
0.16
0.0
2928.0
0.0
142857.0
0.0
1.0
0.0
1072.0
0.0
2857.0
0.0
2000.0
0.0
100.0
0.0
0.0
0.0
2.0
0.0015
100.0
0.16
1000.0
0.0
96480.0
10.0
8314.0
1.0
2857.0
10.0
0.437037
0.0
0.01
2000.0
142857.0
1.188
5.46296
0.0
0.263
0.16
0.16
2857.0
1072.0
0.1
2.0
6.0
200.0
0.0
0.8
0.0
0.01
(1.0 / 602.0)
10.0
0.05
1.0
0.05
1.0
2928.0
1072.0
300.0
100.0
0.045
1000.0
50.0
0.05
( - (DAG_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP2_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PI_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PH_GFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol) + (IP3_PHGFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol))
(((DAG_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PI_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + K_PH_GFP_Cyt_total - (IP3_PHGFP_Cyt * (1.0 - VolFract_Nucleus) * VolFract_Cytosol)) / ((1.0 - VolFract_Nucleus) * VolFract_Cytosol))
(kf_PIP2PH * KdPIP2PH)
((DAG_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PHGFP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PI_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))
(( - (DAG_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP2_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + K_PIP2_PHGFP_PM_total - (PI_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))
(((kf_PIP2PH * PH_GFP_Cyt) * PIP2_PM) - (kr_PIP2PH * PIP2_PHGFP_PM))
((t > tau0) * exp( - ((t - tau0) / stimdecay)))
(kStimSynPIP2 * exp( - ((t - tauPIP2syn) / PIP2syndecay)) * (t > tauPIP2syn))
((PLC_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PLC_act_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))
((K_PLC_PM_total - (PLC_act_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))
((KfPLCact * (PLC_PM * stim_PM * signal)) - (krPLCact * PLC_act_PM))
((kBasalSynPIP * 0.581 * ( - 1.0 + exp(((PIP_basal - PIP_PM) / PIP_basal)))) * (PIP_PM < PIP_basal))
(kStimSynPIP * exp( - ((t - tauPIPsyn) / PIPsyndecay)) * (t > tauPIPsyn))
((Ratebasal_PIPsyn + Ratestim_PIPsyn) * PI_PM)
(k_PIP2hyd * (PIP2_PM * PLC_act_PM))
((kBasalSynPIP2 * 0.581 * ( - 1.0 + exp(((PIP2_basal - PIP2_PM) / PIP2_basal)))) * (PIP2_PM < PIP2_basal))
((Rate_PIP2Synbasal + Rate_PIP2SynStim) * PIP_PM)
SurfToVol_NM
(kf_IP3PH * KdIP3PH)
(((kf_IP3PH * IP3_Cyt) * PH_GFP_Cyt) - (kr_IP3PH * IP3_PHGFP_Cyt))
(SurfToVol_NM * VolFract_Nucleus / (1.0 - VolFract_Nucleus))
(SurfToVol_PM / (1.0 - VolFract_Nucleus))
0.0
(kIP3deg * (IP3_Cyt - IP3_basal))
(SurfToVol_PM * VolFract_Cytosol / (1.0 - VolFract_Cytosol))
(k_PIP2PHhyd * PLC_act_PM * PIP2_PHGFP_PM)
J_IP3_PHGFP
IP3_PHGFP_Cyt_init
((RatePIP2_PH_hyd * Kflux_PM_Cytosol * KMOLE) + (Rate_PIP2_hyd * Kflux_PM_Cytosol * KMOLE) - Rate_IP3deg - J_IP3_PHGFP)
IP3_Cyt_init
- Rate_PIPSyn
PI_PM_init
( - Rate_PIP2_hyd - J_PIP2_PH + Rate_PIP2Syn)
PIP2_PM_init
( - Rate_PIP2Syn + Rate_PIPSyn)
PIP_PM_init
(Rate_PIP2_hyd + RatePIP2_PH_hyd)
DAG_PM_init
RatePLCact
PLC_act_PM_init
2.0
1.0
0.16
2.0
0.8
0.0
300.0
0.1
0.05
0.048
0.1
5.0E-4
2000.0
0.0
142857.0
0.0
0.92
4000.0
0.0
1000.0
1.0
0.0
1.0
0.0055
0.5
2857.0
0.0
1.0
0.12
0.0
0.16
0.0
8314.0
0.0
0.05
10.0
0.019
2857.0
4000.0
(1.0 / 602.0)
0.08
1.0
0.05
2.4
100.0
96480.0
1.0
S:V=.5 optimized rates
2.0
1.0
0.16
0.1
0.8
3.6923
300.0
0.1
0.05
0.048
0.1
5.0E-4
2000.0
0.0
142857.0
0.0
0.92
4000.0
0.0
1000.0
1.0
2.30769
1.0
0.0055
0.5
2857.0
4617.4
1.0
0.12
0.0
0.16
0.0
8314.0
0.0
0.05
10.0
0.019
2857.0
4000.0
(1.0 / 602.0)
0.08
1.0
0.05
2.4
100.0
96480.0
1.0
S:V=.5 optimized rates
2.0
1.0
0.16
0.1
0.8
(3.6923 * 3.0)
300.0
0.1
0.05
0.048
0.1
5.0E-4
2000.0
0.0
142857.0
0.0
0.92
4000.0
0.0
1000.0
1.0
(2.30769 * 3.0)
1.0
0.0055
0.5
2857.0
(4617.4 * 3.0)
1.0
0.12
0.0
0.16
0.0
8314.0
0.0
0.05
10.0
0.019
2857.0
4000.0
(1.0 / 602.0)
0.08
1.0
0.05
2.4
100.0
96480.0
1.0
S:V=.5 optimized rates
2.0
1.0
0.16
0.1
0.8
(3.6923 * 0.3)
300.0
0.1
0.05
0.048
0.1
5.0E-4
2000.0
0.0
142857.0
0.0
0.92
4000.0
0.0
1000.0
1.0
(2.30769 * 0.3)
1.0
0.0055
0.5
2857.0
(4617.4 * 0.3)
1.0
0.12
0.0
0.16
0.0
8314.0
0.0
0.05
10.0
0.019
2857.0
4000.0
(1.0 / 602.0)
0.08
1.0
0.05
2.4
100.0
96480.0
1.0
S:V=.5 optimized rates
2.0
1.0
0.16
0.1
0.8
3.6923
300.0
0.1
0.05
0.048
0.1
5.0E-4
2000.0
0.0
142857.0
0.0
0.0
4000.0
0.0
1000.0
1.0
2.30769
1.0
0.0055
0.5
2857.0
4617.4
1.0
0.12
0.0
0.16
0.0
8314.0
0.0
0.05
10.0
0.0
2857.0
4000.0
(1.0 / 602.0)
0.08
1.0
0.05
2.4
100.0
96480.0
1.0
S:V=.5 optimized rates
(copied from uncaging) (copied from Average Exp Params - Comp) (copied from SS for Exp params) (copied from steady state compartment)
2.30769
0.0
3.6923
0.0
0.0
0.0
0.0
0.0
0.16
0.0
4617.4
0.0
142857.0
0.0
1.0
0.0
4000.0
0.0
2857.0
0.0
2000.0
0.0
100.0
0.0
0.0
0.0
2.0
0.0015
100.0
0.16
1000.0
0.0
96480.0
10.0
8314.0
1.0
2857.0
10.0
3.6923
0.0
0.01
2000.0
142857.0
1.188
2.30769
0.0
0.5
0.16
0.16
2857.0
4000.0
0.1
2.0
6.0
200.0
0.0
0.8
0.0
0.01
(1.0 / 602.0)
10.0
0.05
1.0
0.05
1.0
4617.4
1072.0
300.0
100.0
0.045
1000.0
0.16
50.0
0.05
( - (DAG_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP2_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PI_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PH_GFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol) + (IP3_PHGFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol))
(((DAG_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PI_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + K_PH_GFP_Cyt_total - (IP3_PHGFP_Cyt * (1.0 - VolFract_Nucleus) * VolFract_Cytosol)) / ((1.0 - VolFract_Nucleus) * VolFract_Cytosol))
(kf_PIP2PH * KdPIP2PH)
((DAG_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PHGFP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PI_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))
(( - (DAG_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP2_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + K_PIP2_PHGFP_PM_total - (PI_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))
(((kf_PIP2PH * PH_GFP_Cyt) * PIP2_PM) - (kr_PIP2PH * PIP2_PHGFP_PM))
((t > tau0) * exp( - ((t - tau0) / stimdecay)))
(kStimSynPIP2 * exp( - ((t - tauPIP2syn) / PIP2syndecay)) * (t > tauPIP2syn))
((PLC_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PLC_act_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))
((K_PLC_PM_total - (PLC_act_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))
((KfPLCact * (PLC_PM * stim_PM * signal)) - (krPLCact * PLC_act_PM))
((kBasalSynPIP * 0.581 * ( - 1.0 + exp(((PIP_basal - PIP_PM) / PIP_basal)))) * (PIP_PM < PIP_basal))
(kStimSynPIP * exp( - ((t - tauPIPsyn) / PIPsyndecay)) * (t > tauPIPsyn))
((Ratebasal_PIPsyn + Ratestim_PIPsyn) * PI_PM)
(k_PIP2hyd * (PIP2_PM * PLC_act_PM))
((kBasalSynPIP2 * 0.581 * ( - 1.0 + exp(((PIP2_basal - PIP2_PM) / PIP2_basal)))) * (PIP2_PM < PIP2_basal))
((Rate_PIP2Synbasal + Rate_PIP2SynStim) * PIP_PM)
SurfToVol_NM
(kf_IP3PH * KdIP3PH)
(((kf_IP3PH * IP3_Cyt) * PH_GFP_Cyt) - (kr_IP3PH * IP3_PHGFP_Cyt))
(SurfToVol_NM * VolFract_Nucleus / (1.0 - VolFract_Nucleus))
(SurfToVol_PM / (1.0 - VolFract_Nucleus))
0.0
(kIP3deg * (IP3_Cyt - IP3_basal))
(SurfToVol_PM * VolFract_Cytosol / (1.0 - VolFract_Cytosol))
(k_PIP2PHhyd * PLC_act_PM * PIP2_PHGFP_PM)
J_IP3_PHGFP
IP3_PHGFP_Cyt_init
- Rate_PIPSyn
PI_PM_init
( - Rate_PIP2_hyd - J_PIP2_PH + Rate_PIP2Syn)
PIP2_PM_init
( - Rate_PIP2Syn + Rate_PIPSyn)
PIP_PM_init
(Rate_PIP2_hyd + RatePIP2_PH_hyd)
DAG_PM_init
RatePLCact
PLC_act_PM_init
0.05
96480.0
0.05
1.0
4000.0
10.0
0.16
0.16
2.30769
1000.0
0.1
0.1
1.0
1.0
0.0
0.12
2000.0
0.0
0.1
5.0E-4
0.0
0.08
2857.0
0.0
300.0
3.6923
100.0
0.0
1.0
(1.0 / 602.0)
2857.0
0.8
1.0
2.0
4000.0
0.5
0.05
142857.0
0.019
0.0055
0.0
1.0
0.048
0.16
4617.4
2.4
8314.0
0.92
0.05
96480.0
0.05
1.0
4000.0
10.0
0.16
0.16
(2.30769 * 3.0)
1000.0
0.1
0.1
1.0
1.0
0.0
0.12
2000.0
0.0
0.1
5.0E-4
0.0
0.08
2857.0
0.0
300.0
(3.6923 * 3.0)
100.0
0.0
1.0
(1.0 / 602.0)
2857.0
0.8
1.0
2.0
4000.0
0.5
0.05
142857.0
0.019
0.0055
0.0
1.0
0.048
0.16
(4617.4 * 3.0)
2.4
8314.0
0.92
0.05
96480.0
0.05
1.0
4000.0
10.0
0.16
0.16
(2.30769 * 0.3)
1000.0
0.1
0.1
1.0
1.0
0.0
0.12
2000.0
0.0
0.1
5.0E-4
0.0
0.08
2857.0
0.0
300.0
(3.6923 * 0.3)
100.0
0.0
1.0
(1.0 / 602.0)
2857.0
0.8
1.0
2.0
4000.0
0.5
0.05
142857.0
0.019
0.0055
0.0
1.0
0.048
0.16
(4617.4 * 0.3)
2.4
8314.0
0.92
0.05
96480.0
0.05
1.0
4000.0
10.0
0.16
0.16
2.30769
1000.0
0.1
0.1
1.0
1.0
0.0
0.12
2000.0
0.0
0.1
5.0E-4
0.0
0.08
2857.0
0.0
300.0
3.6923
100.0
0.0
1.0
(1.0 / 602.0)
2857.0
0.8
1.0
0.1
4000.0
0.5
0.05
142857.0
0.019
0.0055
0.0
1.0
0.048
0.16
92307.6
2.4
8314.0
0.92
(copied from Compartmental Sim) (copied from uncaging) (copied from Average Exp Params - Comp) (copied from SS for Exp params) (copied from steady state compartment)
2.30769
0.0
3.6923
0.0
0.0
0.0
0.0
0.0
0.16
0.0
4617.4
0.0
142857.0
0.0
1.0
0.0
4000.0
0.0
2857.0
0.0
2000.0
0.0
100.0
0.0
0.0
0.0
2.0
0.0015
100.0
0.16
1000.0
0.0
96480.0
10.0
8314.0
1.0
2857.0
10.0
3.6923
0.0
0.01
2000.0
142857.0
1.188
2.30769
0.0
0.5
0.16
0.16
2857.0
4000.0
0.1
2.0
6.0
200.0
0.0
0.8
0.0
0.01
(1.0 / 602.0)
10.0
0.05
1.0
0.05
1.0
4617.4
1072.0
300.0
100.0
0.045
4000.0
1000.0
50.0
0.05
((PIP2_PHGFP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PH_GFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol) + (IP3_PHGFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol))
(( - (PIP2_PHGFP_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + K_PH_GFP_Cyt_total - (IP3_PHGFP_Cyt * (1.0 - VolFract_Nucleus) * VolFract_Cytosol)) / ((1.0 - VolFract_Nucleus) * VolFract_Cytosol))
(kf_PIP2PH * KdPIP2PH)
(((kf_PIP2PH * PH_GFP_Cyt) * PIP2_PM) - (kr_PIP2PH * PIP2_PHGFP_PM))
((t > tau0) * exp( - ((t - tau0) / stimdecay)))
(kStimSynPIP2 * exp( - ((t - tauPIP2syn) / PIP2syndecay)) * (t > tauPIP2syn))
((PLC_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PLC_act_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))
((K_PLC_PM_total - (PLC_act_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))
((KfPLCact * (PLC_PM * stim_PM * signal)) - (krPLCact * PLC_act_PM))
((kBasalSynPIP * 0.581 * ( - 1.0 + exp(((PIP_basal - PIP_PM) / PIP_basal)))) * (PIP_PM < PIP_basal))
(kStimSynPIP * exp( - ((t - tauPIPsyn) / PIPsyndecay)) * (t > tauPIPsyn))
((Ratebasal_PIPsyn + Ratestim_PIPsyn) * PI_PM)
(k_PIP2hyd * (PIP2_PM * PLC_act_PM))
((kBasalSynPIP2 * 0.581 * ( - 1.0 + exp(((PIP2_basal - PIP2_PM) / PIP2_basal)))) * (PIP2_PM < PIP2_basal))
((Rate_PIP2Synbasal + Rate_PIP2SynStim) * PIP_PM)
SurfToVol_NM
(kf_IP3PH * KdIP3PH)
(((kf_IP3PH * IP3_Cyt) * PH_GFP_Cyt) - (kr_IP3PH * IP3_PHGFP_Cyt))
(SurfToVol_NM * VolFract_Nucleus / (1.0 - VolFract_Nucleus))
(SurfToVol_PM / (1.0 - VolFract_Nucleus))
0.0
(kIP3deg * (IP3_Cyt - IP3_basal))
(SurfToVol_PM * VolFract_Cytosol / (1.0 - VolFract_Cytosol))
(k_PIP2PHhyd * PLC_act_PM * PIP2_PHGFP_PM)
J_IP3_PHGFP
IP3_PHGFP_Cyt_init
((RatePIP2_PH_hyd * Kflux_PM_Cytosol * KMOLE) + (Rate_PIP2_hyd * Kflux_PM_Cytosol * KMOLE) - Rate_IP3deg - J_IP3_PHGFP)
IP3_Cyt_init
(J_PIP2_PH - RatePIP2_PH_hyd)
PIP2_PHGFP_PM_init
- Rate_PIPSyn
PI_PM_init
( - Rate_PIP2Syn + Rate_PIPSyn)
PIP_PM_init
(Rate_PIP2_hyd + RatePIP2_PH_hyd)
DAG_PM_init
RatePLCact
PLC_act_PM_init
0.05
96480.0
0.05
1.0
4000.0
10.0
0.16
0.16
2.30769
1000.0
0.1
0.1
1.0
1.0
0.0
0.12
2000.0
0.0
0.1
5.0E-4
0.0
0.08
2857.0
0.0
300.0
3.6923
100.0
0.0
1.0
(1.0 / 602.0)
2857.0
0.8
1.0
2.0
4000.0
0.5
0.05
142857.0
0.019
0.0055
0.0
4000.0
1.0
0.048
4617.4
2.4
8314.0
0.92
0.05
96480.0
0.05
1.0
4000.0
10.0
0.16
0.16
(2.30769 * 0.3)
1000.0
0.1
0.1
1.0
1.0
0.0
0.12
2000.0
0.0
0.1
5.0E-4
0.0
0.08
2857.0
0.0
300.0
(3.6923 * 0.3)
100.0
0.0
1.0
(1.0 / 602.0)
2857.0
0.8
1.0
2.0
4000.0
0.5
0.05
142857.0
0.019
0.0055
0.0
4000.0
1.0
0.048
(4617.4 * 0.3)
2.4
8314.0
0.92
0.05
96480.0
0.05
1.0
4000.0
10.0
0.16
0.16
(2.30769 * 3.0)
1000.0
0.1
0.1
1.0
1.0
0.0
0.12
2000.0
0.0
0.1
5.0E-4
0.0
0.08
2857.0
0.0
300.0
(3.6923 * 3.0)
100.0
0.0
1.0
(1.0 / 602.0)
2857.0
0.8
1.0
2.0
4000.0
0.5
0.05
142857.0
0.019
0.0055
0.0
4000.0
1.0
0.048
(4617.4 * 3.0)
2.4
8314.0
0.92
0.05
96480.0
0.05
1.0
4000.0
10.0
0.16
0.16
2.30769
1000.0
0.1
0.1
1.0
1.0
0.0
0.12
2000.0
0.0
0.1
5.0E-4
0.0
0.08
2857.0
0.0
300.0
3.6923
100.0
0.0