Christopher P. Fall, Eric S. Marland, John M. Wagner, John J. Tyson.
http://www.computationalcellbiology.net/

To access, view or copy some of the models described in this book, log on to the Virtual Cell software. Go to File>Open>BioModel. In the BioModel Database dialog, scroll down and open Model Neighborhood. The models can be found under user 'CompCell'.

The models from the text were implemented into the Virtual Cell by Johann Frederick Cutiongco.

The following models are available:

• Chay-Keizer ER - Models pancreatic beta-cell bursting. Described in 5.4 and illustrated in Figure 5.21.
• Hodgkin-Huxley - Models electrical behavior of the squid giant axon. Used to demonstrate interacting ion channels. Described in 2.5.
• Keizer-Levine Open-Cell - Models calcium oscillations in bullfrog sympathetic ganglion neurons via RyR channel kinetics. Described in 5.2.3 and illustrated in Figure 5.8.
• L-Type Calcium Channels - Models L-type calcium channel kinetics in the Aplysia neuron. Used to demonstrate the rapid equilibrium approximation. Described in 4.1 and illustrated in Figure 4.3.
• Morris-Lecar Coincidence Detection - Demonstrates coincidence detection for excitatory inputs. Described in 6.4 and illustrated in Figure 6.9.
• Morris-Lecar Gap Junction Coupled - Demonstrates electrical coupling and gap junctions. Described in 6.1.
• Morris-Lecar Mutual Excitation - Demonstrates how fast excitatory synapses lead to synchrony and slow excitatory synapses lead to asynchrony in two identically electrically coupled cells. The only parameter modified is beta (=1000/s in Figure 6.6A and =100/s in Figure 6.6C). Described in 6.3.
• Morris-Lecar Mutual Inhibition - Demonstrates how fast inhibition leads to antiphase behavior (for t<0.8, beta=1000/s) and slow inhibition leads to in-phase behavior (for t>0.8s, beta=100/s). SurfToVol_PlasmaMembrane 1 and SurfToVol_PlasmaMembrane 2 were changed to 1806 to cancel out KMOLE in the equations for s1 and s2 kinetics. Described in 6.3 and illustrated in Figure 6.7.
• Morris-Lecar Mutual Type II - Models electrical behavior of barnacle muscle fiber. Used to demonstrate interacting ion channels. Described in 2.4.