<BioModel Annotation='This model is intended for anlaysis of PH-GFP experiments and includes binding of the probe to both PIP2 on the plasma membrane and IP3 in the cytosol. The system is based on bradykinin induced calcium release mediated by IP3 in N1E-115 neuroblastoma cells.' Name='PIP2 Hydrolysis JCB Submission'>
  <Model Annotation='' Name='unnamed'>
    <Compound Annotation='PIP2_PHGFP' Name='PIP2_PHGFP' />
    <Compound Annotation='Pleckstrin homology domain_GFP' Name='PH_GFP' />
    <Compound Annotation='Phosphatidylinositol' Name='PI' />
    <Compound Annotation='stimulus' Name='stim' />
    <Compound Annotation='IP3_PHGFP' Name='IP3_PHGFP' />
    <Compound Annotation='Phosphatidylinositolbisphosphate' Name='PIP2' />
    <Compound Annotation='Phosphatidylinositol 4-phosphate' Name='PIP' />
    <Compound Annotation='Diacylglycerol' Name='DAG' />
    <Compound Annotation='photon' Name='hv' />
    <Compound Annotation='Caged_IP3' Name='IP3X' />
    <Compound Annotation='Phospholipase C' Name='PLC' />
    <Compound Annotation='1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase' Name='PLC_act' />
    <Compound Annotation='Inositol-1,4,5-trisphosphate' Name='IP3' />
    <Feature Name='Cytosol' />
    <Feature Name='Nucleus' />
    <Feature Name='Extraclellular' />
    <Membrane InsideFeature='Nucleus' OutsideFeature='Cytosol' MembraneVoltage='Voltage_Membrane0' Name='NM' />
    <Membrane InsideFeature='Cytosol' OutsideFeature='Extraclellular' MembraneVoltage='Voltage_Membrane0' Name='PM' />
    <LocalizedCompound CompoundRef='PIP2_PHGFP' OverrideName='false' Structure='PM' Name='PIP2_PHGFP_PM' />
    <LocalizedCompound CompoundRef='PH_GFP' OverrideName='true' Structure='Cytosol' Name='PH_GFP_Cyt' />
    <LocalizedCompound CompoundRef='PI' OverrideName='false' Structure='PM' Name='PI_PM' />
    <LocalizedCompound CompoundRef='stim' OverrideName='false' Structure='PM' Name='stim_PM' />
    <LocalizedCompound CompoundRef='IP3_PHGFP' OverrideName='true' Structure='Cytosol' Name='IP3_PHGFP_Cyt' />
    <LocalizedCompound CompoundRef='PIP2' OverrideName='false' Structure='PM' Name='PIP2_PM' />
    <LocalizedCompound CompoundRef='PIP' OverrideName='false' Structure='PM' Name='PIP_PM' />
    <LocalizedCompound CompoundRef='DAG' OverrideName='false' Structure='PM' Name='DAG_PM' />
    <LocalizedCompound CompoundRef='hv' OverrideName='false' Structure='Cytosol' Name='hv_Cytosol' />
    <LocalizedCompound CompoundRef='IP3X' OverrideName='false' Structure='Cytosol' Name='IP3X_Cytosol' />
    <LocalizedCompound CompoundRef='PLC' OverrideName='false' Structure='PM' Name='PLC_PM' />
    <LocalizedCompound CompoundRef='PLC_act' OverrideName='false' Structure='PM' Name='PLC_act_PM' />
    <LocalizedCompound CompoundRef='IP3' OverrideName='true' Structure='Cytosol' Name='IP3_Cyt' />
    <SimpleReaction FluxOption='MolecularOnly' FluxCarrierValence='0' Structure='Cytosol' Name='IP3deg'>
      <Reactant Stoichiometry='1' LocalizedCompoundRef='IP3_Cyt' />
      <Kinetics KineticsType='GeneralKinetics'>
        <Parameter Name='Rate_IP3deg'>(kIP3deg * (IP3_Cyt - IP3_basal))</Parameter>
        <Parameter Name='kIP3deg'>0.16</Parameter>
        <Parameter Name='IP3_basal'>0.16</Parameter>
        <Rate>Rate_IP3deg</Rate>
      </Kinetics>
    </SimpleReaction>
    <SimpleReaction FluxOption='MolecularOnly' FluxCarrierValence='0' Structure='Cytosol' Name='IP3-PHGFP'>
      <Reactant Stoichiometry='1' LocalizedCompoundRef='IP3_Cyt' />
      <Reactant Stoichiometry='1' LocalizedCompoundRef='PH_GFP_Cyt' />
      <Product Stoichiometry='1' LocalizedCompoundRef='IP3_PHGFP_Cyt' />
      <Kinetics KineticsType='MassAction'>
        <Parameter Name='kf_IP3PH'>100.0</Parameter>
        <Parameter Name='kr_IP3PH'>(kf_IP3PH * KdIP3PH)</Parameter>
        <Parameter Name='KdIP3PH'>2.0</Parameter>
        <ForwardRate>kf_IP3PH</ForwardRate>
        <ReverseRate>kr_IP3PH</ReverseRate>
        <Rate>(((kf_IP3PH * IP3_Cyt) * PH_GFP_Cyt) - (kr_IP3PH * IP3_PHGFP_Cyt))</Rate>
      </Kinetics>
    </SimpleReaction>
    <SimpleReaction FluxOption='MolecularOnly' FluxCarrierValence='0' Structure='PM' Name='PIP2_PH'>
      <Reactant Stoichiometry='1' LocalizedCompoundRef='PH_GFP_Cyt' />
      <Product Stoichiometry='1' LocalizedCompoundRef='PIP2_PHGFP_PM' />
      <Reactant Stoichiometry='1' LocalizedCompoundRef='PIP2_PM' />
      <Kinetics KineticsType='MassAction'>
        <Parameter Name='kf_PIP2PH'>200.0</Parameter>
        <Parameter Name='kr_PIP2PH'>(kf_PIP2PH * KdPIP2PH)</Parameter>
        <Parameter Name='KdPIP2PH'>2.0</Parameter>
        <ForwardRate>kf_PIP2PH</ForwardRate>
        <ReverseRate>kr_PIP2PH</ReverseRate>
        <Rate>(((kf_PIP2PH * PH_GFP_Cyt) * PIP2_PM) - (kr_PIP2PH * PIP2_PHGFP_PM))</Rate>
      </Kinetics>
    </SimpleReaction>
    <SimpleReaction FluxOption='MolecularOnly' FluxCarrierValence='0' Structure='PM' Name='PIP2Syn'>
      <Reactant Stoichiometry='1' LocalizedCompoundRef='PIP_PM' />
      <Product Stoichiometry='1' LocalizedCompoundRef='PIP2_PM' />
      <Kinetics KineticsType='GeneralKinetics'>
        <Parameter Name='Rate_PIP2Syn'>((Rate_PIP2Synbasal + Rate_PIP2SynStim) * PIP_PM)</Parameter>
        <Parameter Name='Rate_PIP2Synbasal'>((kBasalSynPIP2 * 0.581 * ( - 1.0 + exp(((PIP2_basal - PIP2_PM) / PIP2_basal)))) * (PIP2_PM &amp;lt; PIP2_basal))</Parameter>
        <Parameter Name='Rate_PIP2SynStim'>(kStimSynPIP2 * exp( - ((t - tauPIP2syn) / PIP2syndecay)) * (t &amp;gt; tauPIP2syn))</Parameter>
        <Parameter Name='kBasalSynPIP2'>0.045</Parameter>
        <Parameter Name='PIP2_basal'>1072.0</Parameter>
        <Parameter Name='kStimSynPIP2'>0.01</Parameter>
        <Parameter Name='tauPIP2syn'>0.05</Parameter>
        <Parameter Name='PIP2syndecay'>10.0</Parameter>
        <Rate>Rate_PIP2Syn</Rate>
      </Kinetics>
    </SimpleReaction>
    <SimpleReaction FluxOption='MolecularOnly' FluxCarrierValence='0' Structure='PM' Name='PIPSyn'>
      <Reactant Stoichiometry='1' LocalizedCompoundRef='PI_PM' />
      <Product Stoichiometry='1' LocalizedCompoundRef='PIP_PM' />
      <Kinetics KineticsType='GeneralKinetics'>
        <Parameter Name='Rate_PIPSyn'>((Ratebasal_PIPsyn + Ratestim_PIPsyn) * PI_PM)</Parameter>
        <Parameter Name='Ratebasal_PIPsyn'>((kBasalSynPIP * 0.581 * ( - 1.0 + exp(((PIP_basal - PIP_PM) / PIP_basal)))) * (PIP_PM &amp;lt; PIP_basal))</Parameter>
        <Parameter Name='Ratestim_PIPsyn'>(kStimSynPIP * exp( - ((t - tauPIPsyn) / PIPsyndecay)) * (t &amp;gt; tauPIPsyn))</Parameter>
        <Parameter Name='kBasalSynPIP'>0.0015</Parameter>
        <Parameter Name='PIP_basal'>2857.0</Parameter>
        <Parameter Name='kStimSynPIP'>0.01</Parameter>
        <Parameter Name='tauPIPsyn'>0.05</Parameter>
        <Parameter Name='PIPsyndecay'>10.0</Parameter>
        <Rate>Rate_PIPSyn</Rate>
      </Kinetics>
    </SimpleReaction>
    <SimpleReaction FluxOption='MolecularOnly' FluxCarrierValence='0' Structure='PM' Name='PIP2_hyd'>
      <Product Stoichiometry='1' LocalizedCompoundRef='DAG_PM' />
      <Product Stoichiometry='1' LocalizedCompoundRef='IP3_Cyt' />
      <Reactant Stoichiometry='1' LocalizedCompoundRef='PIP2_PM' />
      <Modifier LocalizedCompoundRef='PLC_act_PM' />
      <Kinetics KineticsType='GeneralKinetics'>
        <Parameter Name='Rate_PIP2_hyd'>(k_PIP2hyd * (PIP2_PM * PLC_act_PM))</Parameter>
        <Parameter Name='k_PIP2hyd'>1.188</Parameter>
        <Rate>Rate_PIP2_hyd</Rate>
      </Kinetics>
    </SimpleReaction>
    <SimpleReaction FluxOption='MolecularOnly' FluxCarrierValence='0' Structure='Cytosol' Name='IP3_uncaging'>
      <Product Stoichiometry='1' LocalizedCompoundRef='IP3_Cyt' />
      <Modifier LocalizedCompoundRef='hv_Cytosol' />
      <Reactant Stoichiometry='1' LocalizedCompoundRef='IP3X_Cytosol' />
      <Kinetics KineticsType='GeneralKinetics'>
        <Parameter Name='J_IP3_uncaging'>(intensity * IP3X_Cytosol * hv_Cytosol)</Parameter>
        <Parameter Name='intensity'>100000.0</Parameter>
        <Rate>J_IP3_uncaging</Rate>
      </Kinetics>
    </SimpleReaction>
    <SimpleReaction FluxOption='MolecularOnly' FluxCarrierValence='0' Structure='PM' Name='PLCact'>
      <Reactant Stoichiometry='1' LocalizedCompoundRef='PLC_PM' />
      <Product Stoichiometry='1' LocalizedCompoundRef='PLC_act_PM' />
      <Modifier LocalizedCompoundRef='stim_PM' />
      <Kinetics KineticsType='GeneralKinetics'>
        <Parameter Name='RatePLCact'>((KfPLCact * (PLC_PM * stim_PM * signal)) - (krPLCact * PLC_act_PM))</Parameter>
        <Parameter Name='KfPLCact'>1000.0</Parameter>
        <Parameter Name='signal'>((t &amp;gt; tau0) * exp( - ((t - tau0) / stimdecay)))</Parameter>
        <Parameter Name='krPLCact'>10.0</Parameter>
        <Parameter Name='tau0'>0.05</Parameter>
        <Parameter Name='stimdecay'>6.0</Parameter>
        <Rate>RatePLCact</Rate>
      </Kinetics>
    </SimpleReaction>
    <SimpleReaction FluxOption='MolecularOnly' FluxCarrierValence='0' Structure='PM' Name='PIP2_PH_hyd'>
      <Reactant Stoichiometry='1' LocalizedCompoundRef='PIP2_PHGFP_PM' />
      <Product Stoichiometry='1' LocalizedCompoundRef='PH_GFP_Cyt' />
      <Product Stoichiometry='1' LocalizedCompoundRef='IP3_Cyt' />
      <Modifier LocalizedCompoundRef='PLC_act_PM' />
      <Product Stoichiometry='1' LocalizedCompoundRef='DAG_PM' />
      <Kinetics KineticsType='GeneralKinetics'>
        <Parameter Name='RatePIP2_PH_hyd'>(k_PIP2PHhyd * PLC_act_PM * PIP2_PHGFP_PM)</Parameter>
        <Parameter Name='k_PIP2PHhyd'>50.0</Parameter>
        <Rate>RatePIP2_PH_hyd</Rate>
      </Kinetics>
    </SimpleReaction>
    <Diagram Structure='PM' Name='Membrane0'>
      <LocalizedCompoundShape LocationX='177' LocationY='305' LocalizedCompoundRef='PIP2_PHGFP_PM' />
      <LocalizedCompoundShape LocationX='49' LocationY='54' LocalizedCompoundRef='PI_PM' />
      <LocalizedCompoundShape LocationX='123' LocationY='342' LocalizedCompoundRef='stim_PM' />
      <LocalizedCompoundShape LocationX='25' LocationY='350' LocalizedCompoundRef='PIP2_PM' />
      <LocalizedCompoundShape LocationX='66' LocationY='182' LocalizedCompoundRef='PIP_PM' />
      <LocalizedCompoundShape LocationX='331' LocationY='429' LocalizedCompoundRef='DAG_PM' />
      <LocalizedCompoundShape LocationX='143' LocationY='410' LocalizedCompoundRef='PLC_PM' />
      <LocalizedCompoundShape LocationX='247' LocationY='407' LocalizedCompoundRef='PLC_act_PM' />
      <LocalizedCompoundShape LocationX='41' LocationY='160' LocalizedCompoundRef='PH_GFP_Cyt' />
      <LocalizedCompoundShape LocationX='30' LocationY='102' LocalizedCompoundRef='IP3_PHGFP_Cyt' />
      <LocalizedCompoundShape LocationX='60' LocationY='50' LocalizedCompoundRef='hv_Cytosol' />
      <LocalizedCompoundShape LocationX='18' LocationY='49' LocalizedCompoundRef='IP3X_Cytosol' />
      <LocalizedCompoundShape LocationX='43' LocationY='448' LocalizedCompoundRef='IP3_Cyt' />
      <SimpleReactionShape LocationX='274' LocationY='231' SimpleReactionRef='PIP2_PH' />
      <SimpleReactionShape LocationX='76' LocationY='247' SimpleReactionRef='PIP2Syn' />
      <SimpleReactionShape LocationX='54' LocationY='122' SimpleReactionRef='PIPSyn' />
      <SimpleReactionShape LocationX='177' LocationY='473' SimpleReactionRef='PIP2_hyd' />
      <SimpleReactionShape LocationX='183' LocationY='395' SimpleReactionRef='PLCact' />
      <SimpleReactionShape LocationX='273' LocationY='329' SimpleReactionRef='PIP2_PH_hyd' />
    </Diagram>
    <Diagram Structure='Extraclellular' Name='unnamed' />
    <Diagram Structure='NM' Name='Membrane0' />
    <Diagram Structure='Cytosol' Name='Feature0'>
      <LocalizedCompoundShape LocationX='153' LocationY='155' LocalizedCompoundRef='IP3_Cyt' />
      <LocalizedCompoundShape LocationX='27' LocationY='21' LocalizedCompoundRef='PLC_Cyt' />
      <LocalizedCompoundShape LocationX='107' LocationY='286' LocalizedCompoundRef='PH_GFP_Cyt' />
      <LocalizedCompoundShape LocationX='321' LocationY='233' LocalizedCompoundRef='IP3_PHGFP_Cyt' />
      <LocalizedCompoundShape LocationX='110' LocationY='39' LocalizedCompoundRef='hv_Cytosol' />
      <LocalizedCompoundShape LocationX='36' LocationY='79' LocalizedCompoundRef='IP3X_Cytosol' />
      <SimpleReactionShape LocationX='249' LocationY='97' SimpleReactionRef='IP3deg' />
      <SimpleReactionShape LocationX='206' LocationY='229' SimpleReactionRef='IP3-PHGFP' />
      <SimpleReactionShape LocationX='80' LocationY='102' SimpleReactionRef='reaction0' />
    </Diagram>
    <Diagram Structure='Nucleus' Name='Feature0' />
    <Version FromVersionable='true' Name='unnamed'></Version>
  </Model>
  <SimulationSpec Annotation='' Name='steady state compartment'>
    <Geometry Dimension='0' Annotation='' Name='steady state compartment'>
      <Extent X='10.0' Y='10.0' Z='10.0' />
      <Origin X='0.0' Y='0.0' Z='0.0' />
      <SubVolume Handle='0' Type='Compartmental' Name='Compartment' />
      <Version FromVersionable='true' Name='steady state compartment'></Version>
    </Geometry>
    <GeometryContext>
      <FeatureMapping Resolved='false' Feature='Cytosol' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <FeatureMapping Resolved='false' Feature='Nucleus' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <FeatureMapping Resolved='false' Feature='Extraclellular' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <MembraneMapping Membrane='NM' SurfaceToVolumeRatio='1.0' SpecificCapacitance='0.01' InitialVoltage='0.0' VolumeFraction='0.1' CalculateVoltage='false' />
      <MembraneMapping Membrane='PM' SurfaceToVolumeRatio='0.263' SpecificCapacitance='0.01' InitialVoltage='0.0' VolumeFraction='0.8' CalculateVoltage='false' />
    </GeometryContext>
    <ReactionContext>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='PH_GFP_Cyt' EnableDiffusion='true'>
        <Initial>1.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='IP3_PHGFP_Cyt' EnableDiffusion='true'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='hv_Cytosol' EnableDiffusion='true'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='IP3X_Cytosol' EnableDiffusion='true'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='IP3_Cyt' EnableDiffusion='true'>
        <Initial>0.16</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP2_PHGFP_PM' EnableDiffusion='false'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='PI_PM' EnableDiffusion='false'>
        <Initial>1200000.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='stim_PM' EnableDiffusion='false'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='PIP2_PM' EnableDiffusion='false'>
        <Initial>12000.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP_PM' EnableDiffusion='false'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='DAG_PM' EnableDiffusion='false'>
        <Initial>2000.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PLC_PM' EnableDiffusion='false'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PLC_act_PM' EnableDiffusion='false'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3deg' />
      <ReactionSpec ReactionMapping='fast' ReactionStepRef='IP3-PHGFP' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_PH' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2Syn' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIPSyn' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_hyd' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3_uncaging' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PLCact' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_PH_hyd' />
    </ReactionContext>
    <MathDescription Annotation='' Name='steady state compartment'>
      <Constant Name='KdPIP2PH'>2.0</Constant>
      <Constant Name='kBasalSynPIP'>0.0015</Constant>
      <Constant Name='PLC_PM_init'>0.0</Constant>
      <Constant Name='IP3_Cyt_init'>0.16</Constant>
      <Constant Name='intensity'>100000.0</Constant>
      <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
      <Constant Name='hv_Cytosol_init'>0.0</Constant>
      <Constant Name='_F_'>96480.0</Constant>
      <Constant Name='PIP2syndecay'>10.0</Constant>
      <Constant Name='_R_'>8314.0</Constant>
      <Constant Name='stim_PM'>0.0</Constant>
      <Constant Name='PIP_basal'>2857.0</Constant>
      <Constant Name='PIPsyndecay'>10.0</Constant>
      <Constant Name='IP3_PHGFP_Cyt_init'>0.0</Constant>
      <Constant Name='kStimSynPIP'>0.01</Constant>
      <Constant Name='DAG_PM_init'>2000.0</Constant>
      <Constant Name='PI_PM_init'>1200000.0</Constant>
      <Constant Name='k_PIP2hyd'>1.188</Constant>
      <Constant Name='PH_GFP_Cyt_init'>1.0</Constant>
      <Constant Name='SurfToVol_PM'>0.263</Constant>
      <Constant Name='kIP3deg'>0.16</Constant>
      <Constant Name='PI_PM'>1200000.0</Constant>
      <Constant Name='IP3_basal'>0.16</Constant>
      <Constant Name='PIP_PM_init'>0.0</Constant>
      <Constant Name='PIP2_PM_init'>12000.0</Constant>
      <Constant Name='VolFract_Nucleus'>0.1</Constant>
      <Constant Name='KdIP3PH'>2.0</Constant>
      <Constant Name='stimdecay'>6.0</Constant>
      <Constant Name='kf_PIP2PH'>200.0</Constant>
      <Constant Name='PLC_act_PM_init'>0.0</Constant>
      <Constant Name='VolFract_Cytosol'>0.8</Constant>
      <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
      <Constant Name='kStimSynPIP2'>0.01</Constant>
      <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
      <Constant Name='PH_GFP_Cyt'>1.0</Constant>
      <Constant Name='krPLCact'>10.0</Constant>
      <Constant Name='tau0'>0.05</Constant>
      <Constant Name='SurfToVol_NM'>1.0</Constant>
      <Constant Name='tauPIPsyn'>0.05</Constant>
      <Constant Name='stim_PM_init'>0.0</Constant>
      <Constant Name='PIP2_PHGFP_PM_init'>0.0</Constant>
      <Constant Name='PIP2_basal'>1072.0</Constant>
      <Constant Name='_T_'>300.0</Constant>
      <Constant Name='kf_IP3PH'>100.0</Constant>
      <Constant Name='kBasalSynPIP2'>0.045</Constant>
      <Constant Name='PIP2_PM'>12000.0</Constant>
      <Constant Name='KfPLCact'>1000.0</Constant>
      <Constant Name='IP3_Cyt'>0.16</Constant>
      <Constant Name='k_PIP2PHhyd'>50.0</Constant>
      <Constant Name='tauPIP2syn'>0.05</Constant>
      <VolumeVariable Name='IP3_PHGFP_Cyt' />
      <VolumeVariable Name='PIP2_PHGFP_PM' />
      <VolumeVariable Name='IP3X_Cytosol' />
      <VolumeVariable Name='PLC_act_PM' />
      <VolumeVariable Name='PIP_PM' />
      <VolumeVariable Name='DAG_PM' />
      <Function Name='kr_PIP2PH'>(kf_PIP2PH * KdPIP2PH)</Function>
      <Function Name='J_PIP2_PH'>(((kf_PIP2PH * PH_GFP_Cyt) * PIP2_PM) - (kr_PIP2PH * PIP2_PHGFP_PM))</Function>
      <Function Name='signal'>((t &amp;gt; tau0) * exp( - ((t - tau0) / stimdecay)))</Function>
      <Function Name='Rate_PIP2SynStim'>(kStimSynPIP2 * exp( - ((t - tauPIP2syn) / PIP2syndecay)) * (t &amp;gt; tauPIP2syn))</Function>
      <Function Name='K_PLC_PM_total'>((PLC_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PLC_act_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='PLC_PM'>((K_PLC_PM_total - (PLC_act_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='RatePLCact'>((KfPLCact * (PLC_PM * stim_PM * signal)) - (krPLCact * PLC_act_PM))</Function>
      <Function Name='Ratebasal_PIPsyn'>((kBasalSynPIP * 0.581 * ( - 1.0 + exp(((PIP_basal - PIP_PM) / PIP_basal)))) * (PIP_PM &amp;lt; PIP_basal))</Function>
      <Function Name='Ratestim_PIPsyn'>(kStimSynPIP * exp( - ((t - tauPIPsyn) / PIPsyndecay)) * (t &amp;gt; tauPIPsyn))</Function>
      <Function Name='Rate_PIPSyn'>((Ratebasal_PIPsyn + Ratestim_PIPsyn) * PI_PM)</Function>
      <Function Name='Rate_PIP2_hyd'>(k_PIP2hyd * (PIP2_PM * PLC_act_PM))</Function>
      <Function Name='K_hv_Cytosol_total'>(hv_Cytosol_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol)</Function>
      <Function Name='hv_Cytosol'>(K_hv_Cytosol_total / ((1.0 - VolFract_Nucleus) * VolFract_Cytosol))</Function>
      <Function Name='Rate_PIP2Synbasal'>((kBasalSynPIP2 * 0.581 * ( - 1.0 + exp(((PIP2_basal - PIP2_PM) / PIP2_basal)))) * (PIP2_PM &amp;lt; PIP2_basal))</Function>
      <Function Name='Rate_PIP2Syn'>((Rate_PIP2Synbasal + Rate_PIP2SynStim) * PIP_PM)</Function>
      <Function Name='Kflux_NM_Nucleus'>SurfToVol_NM</Function>
      <Function Name='kr_IP3PH'>(kf_IP3PH * KdIP3PH)</Function>
      <Function Name='J_IP3_PHGFP'>(((kf_IP3PH * IP3_Cyt) * PH_GFP_Cyt) - (kr_IP3PH * IP3_PHGFP_Cyt))</Function>
      <Function Name='Kflux_NM_Cytosol'>(SurfToVol_NM * VolFract_Nucleus / (1.0 - VolFract_Nucleus))</Function>
      <Function Name='Kflux_PM_Cytosol'>(SurfToVol_PM / (1.0 - VolFract_Nucleus))</Function>
      <Function Name='Voltage_Membrane0'>0.0</Function>
      <Function Name='Rate_IP3deg'>(kIP3deg * (IP3_Cyt - IP3_basal))</Function>
      <Function Name='Kflux_PM_Extraclellular'>(SurfToVol_PM * VolFract_Cytosol / (1.0 - VolFract_Cytosol))</Function>
      <Function Name='J_IP3_uncaging'>(intensity * IP3X_Cytosol * hv_Cytosol)</Function>
      <Function Name='RatePIP2_PH_hyd'>(k_PIP2PHhyd * PLC_act_PM * PIP2_PHGFP_PM)</Function>
      <CompartmentSubDomain Name='Compartment'>
        <BoundaryType Type='Value' Boundary='Xm' />
        <BoundaryType Type='Value' Boundary='Xp' />
        <BoundaryType Type='Value' Boundary='Ym' />
        <BoundaryType Type='Value' Boundary='Yp' />
        <BoundaryType Type='Value' Boundary='Zm' />
        <BoundaryType Type='Value' Boundary='Zp' />
        <OdeEquation Name='IP3_PHGFP_Cyt'>
          <Rate>0.0</Rate>
          <Initial>IP3_PHGFP_Cyt_init</Initial>
        </OdeEquation>
        <OdeEquation Name='IP3X_Cytosol'>
          <Rate> - J_IP3_uncaging</Rate>
          <Initial>IP3X_Cytosol_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PIP2_PHGFP_PM'>
          <Rate>(J_PIP2_PH - RatePIP2_PH_hyd)</Rate>
          <Initial>PIP2_PHGFP_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PIP_PM'>
          <Rate>( - Rate_PIP2Syn + Rate_PIPSyn)</Rate>
          <Initial>PIP_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='DAG_PM'>
          <Rate>(Rate_PIP2_hyd + RatePIP2_PH_hyd)</Rate>
          <Initial>DAG_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PLC_act_PM'>
          <Rate>RatePLCact</Rate>
          <Initial>PLC_act_PM_init</Initial>
        </OdeEquation>
        <FastSystem>
          <FastRate>J_IP3_PHGFP</FastRate>
        </FastSystem>
      </CompartmentSubDomain>
      <Version FromVersionable='true' Name='steady state compartment'></Version>
    </MathDescription>
    <Simulation Annotation='Total PIP2 + both complexes =&amp;#10;12,000molec/um2' Name='ss check 1'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='Runge-Kutta-Fehlberg (Fifth Order, Variable Time Step)' KeepEvery='1'>
        <TimeBound StartTime='0.0' EndTime='1.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-8' DefaultTime='0.1' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='PIP2_PM'>4000.0</Constant>
        <Constant Name='intensity'>100000.0</Constant>
        <Constant Name='kf_IP3PH'>100.0</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='kIP3deg'>0.16</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='PIP_PM_init'>0.0</Constant>
        <Constant Name='kStimSynPIP'>0.01</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='PIPsyndecay'>10.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='kBasalSynPIP'>0.0015</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='PI_PM'>142857.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
        <Constant Name='stim_PM'>0.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='krPLCact'>10.0</Constant>
        <Constant Name='kStimSynPIP2'>0.01</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='k_PIP2hyd'>1.188</Constant>
        <Constant Name='kBasalSynPIP2'>0.045</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='KfPLCact'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='stimdecay'>6.0</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>4617.4</Constant>
        <Constant Name='IP3_Cyt'>0.16</Constant>
        <Constant Name='PIP2syndecay'>10.0</Constant>
        <Constant Name='kf_PIP2PH'>200.0</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>3.6923</Constant>
        <Constant Name='stim_PM_init'>0.0</Constant>
        <Constant Name='PH_GFP_Cyt'>2.30769</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='k_PIP2PHhyd'>50.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='SurfToVol_PM'>0.263</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='ss check 1'>Total PIP2 + both complexes =&amp;#10;12,000molec/um2</Version>
    </Simulation>
    <Version FromVersionable='true' Name='steady state compartment'></Version>
  </SimulationSpec>
  <SimulationSpec Annotation='(copied from Average Exp Params - Comp) (copied from SS for Exp params) (copied from steady state compartment) ' Name='uncaging'>
    <Geometry Dimension='0' Annotation='' Name='steady state compartment'>
      <Extent X='10.0' Y='10.0' Z='10.0' />
      <Origin X='0.0' Y='0.0' Z='0.0' />
      <SubVolume Handle='0' Type='Compartmental' Name='Compartment' />
      <Version FromVersionable='true' Name='steady state compartment'></Version>
    </Geometry>
    <GeometryContext>
      <FeatureMapping Resolved='false' Feature='Cytosol' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <FeatureMapping Resolved='false' Feature='Nucleus' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <FeatureMapping Resolved='false' Feature='Extraclellular' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <MembraneMapping Membrane='NM' SurfaceToVolumeRatio='1.0' SpecificCapacitance='0.01' InitialVoltage='0.0' VolumeFraction='0.1' CalculateVoltage='false' />
      <MembraneMapping Membrane='PM' SurfaceToVolumeRatio='0.263' SpecificCapacitance='0.01' InitialVoltage='0.0' VolumeFraction='0.8' CalculateVoltage='false' />
    </GeometryContext>
    <ReactionContext>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PH_GFP_Cyt' EnableDiffusion='true'>
        <Initial>2.30769</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='IP3_PHGFP_Cyt' EnableDiffusion='true'>
        <Initial>3.6923</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='hv_Cytosol' EnableDiffusion='true'>
        <Initial>1.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='IP3X_Cytosol' EnableDiffusion='true'>
        <Initial>1.01446</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='IP3_Cyt' EnableDiffusion='true'>
        <Initial>0.16</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP2_PHGFP_PM' EnableDiffusion='false'>
        <Initial>4617.4</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PI_PM' EnableDiffusion='false'>
        <Initial>142857.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='stim_PM' EnableDiffusion='false'>
        <Initial>1.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP2_PM' EnableDiffusion='false'>
        <Initial>4000.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP_PM' EnableDiffusion='false'>
        <Initial>2857.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='DAG_PM' EnableDiffusion='false'>
        <Initial>2000.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PLC_PM' EnableDiffusion='false'>
        <Initial>100.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PLC_act_PM' EnableDiffusion='false'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3deg' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3-PHGFP' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_PH' />
      <ReactionSpec ReactionMapping='excluded' ReactionStepRef='PIP2Syn' />
      <ReactionSpec ReactionMapping='excluded' ReactionStepRef='PIPSyn' />
      <ReactionSpec ReactionMapping='excluded' ReactionStepRef='PIP2_hyd' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3_uncaging' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PLCact' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_PH_hyd' />
    </ReactionContext>
    <MathDescription Annotation='' Name='Average Exp Params - fast off'>
      <Constant Name='KdPIP2PH'>2.0</Constant>
      <Constant Name='PLC_PM_init'>100.0</Constant>
      <Constant Name='IP3_Cyt_init'>0.16</Constant>
      <Constant Name='intensity'>100000.0</Constant>
      <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
      <Constant Name='hv_Cytosol_init'>1.0</Constant>
      <Constant Name='_F_'>96480.0</Constant>
      <Constant Name='_R_'>8314.0</Constant>
      <Constant Name='stim_PM'>1.0</Constant>
      <Constant Name='IP3_PHGFP_Cyt_init'>3.6923</Constant>
      <Constant Name='DAG_PM_init'>2000.0</Constant>
      <Constant Name='PI_PM_init'>142857.0</Constant>
      <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
      <Constant Name='hv_Cytosol'>1.0</Constant>
      <Constant Name='SurfToVol_PM'>0.263</Constant>
      <Constant Name='kIP3deg'>0.16</Constant>
      <Constant Name='IP3_basal'>0.16</Constant>
      <Constant Name='PIP_PM_init'>2857.0</Constant>
      <Constant Name='PIP2_PM_init'>4000.0</Constant>
      <Constant Name='VolFract_Nucleus'>0.1</Constant>
      <Constant Name='KdIP3PH'>2.0</Constant>
      <Constant Name='stimdecay'>6.0</Constant>
      <Constant Name='kf_PIP2PH'>200.0</Constant>
      <Constant Name='PLC_act_PM_init'>0.0</Constant>
      <Constant Name='VolFract_Cytosol'>0.8</Constant>
      <Constant Name='IP3X_Cytosol_init'>1.01446</Constant>
      <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
      <Constant Name='krPLCact'>10.0</Constant>
      <Constant Name='tau0'>0.05</Constant>
      <Constant Name='SurfToVol_NM'>1.0</Constant>
      <Constant Name='stim_PM_init'>1.0</Constant>
      <Constant Name='PIP2_PHGFP_PM_init'>4617.4</Constant>
      <Constant Name='_T_'>300.0</Constant>
      <Constant Name='kf_IP3PH'>100.0</Constant>
      <Constant Name='KfPLCact'>1000.0</Constant>
      <Constant Name='k_PIP2PHhyd'>50.0</Constant>
      <VolumeVariable Name='IP3_PHGFP_Cyt' />
      <VolumeVariable Name='IP3X_Cytosol' />
      <VolumeVariable Name='PLC_act_PM' />
      <VolumeVariable Name='DAG_PM' />
      <VolumeVariable Name='PIP2_PM' />
      <VolumeVariable Name='IP3_Cyt' />
      <Function Name='K_PI_PM_total'>(PI_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE)</Function>
      <Function Name='K_PH_GFP_Cyt_total'>( - (DAG_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP2_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PH_GFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol) + (IP3_PHGFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol))</Function>
      <Function Name='PH_GFP_Cyt'>(((DAG_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + K_PH_GFP_Cyt_total - (IP3_PHGFP_Cyt * (1.0 - VolFract_Nucleus) * VolFract_Cytosol)) / ((1.0 - VolFract_Nucleus) * VolFract_Cytosol))</Function>
      <Function Name='kr_PIP2PH'>(kf_PIP2PH * KdPIP2PH)</Function>
      <Function Name='K_PIP2_PHGFP_PM_total'>((DAG_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PHGFP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='PIP2_PHGFP_PM'>(( - (DAG_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + K_PIP2_PHGFP_PM_total - (PIP2_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='J_PIP2_PH'>(((kf_PIP2PH * PH_GFP_Cyt) * PIP2_PM) - (kr_PIP2PH * PIP2_PHGFP_PM))</Function>
      <Function Name='signal'>((t &amp;gt; tau0) * exp( - ((t - tau0) / stimdecay)))</Function>
      <Function Name='K_PLC_PM_total'>((PLC_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PLC_act_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='PLC_PM'>((K_PLC_PM_total - (PLC_act_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='RatePLCact'>((KfPLCact * (PLC_PM * stim_PM * signal)) - (krPLCact * PLC_act_PM))</Function>
      <Function Name='K_PIP_PM_total'>(PIP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE)</Function>
      <Function Name='PIP_PM'>(K_PIP_PM_total / (SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='Kflux_NM_Nucleus'>SurfToVol_NM</Function>
      <Function Name='PI_PM'>(K_PI_PM_total / (SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='kr_IP3PH'>(kf_IP3PH * KdIP3PH)</Function>
      <Function Name='J_IP3_PHGFP'>(((kf_IP3PH * IP3_Cyt) * PH_GFP_Cyt) - (kr_IP3PH * IP3_PHGFP_Cyt))</Function>
      <Function Name='Kflux_NM_Cytosol'>(SurfToVol_NM * VolFract_Nucleus / (1.0 - VolFract_Nucleus))</Function>
      <Function Name='Kflux_PM_Cytosol'>(SurfToVol_PM / (1.0 - VolFract_Nucleus))</Function>
      <Function Name='Voltage_Membrane0'>0.0</Function>
      <Function Name='Rate_IP3deg'>(kIP3deg * (IP3_Cyt - IP3_basal))</Function>
      <Function Name='Kflux_PM_Extraclellular'>(SurfToVol_PM * VolFract_Cytosol / (1.0 - VolFract_Cytosol))</Function>
      <Function Name='J_IP3_uncaging'>(intensity * IP3X_Cytosol * hv_Cytosol)</Function>
      <Function Name='RatePIP2_PH_hyd'>(k_PIP2PHhyd * PLC_act_PM * PIP2_PHGFP_PM)</Function>
      <CompartmentSubDomain Name='Compartment'>
        <BoundaryType Type='Value' Boundary='Xm' />
        <BoundaryType Type='Value' Boundary='Xp' />
        <BoundaryType Type='Value' Boundary='Ym' />
        <BoundaryType Type='Value' Boundary='Yp' />
        <BoundaryType Type='Value' Boundary='Zm' />
        <BoundaryType Type='Value' Boundary='Zp' />
        <OdeEquation Name='IP3_PHGFP_Cyt'>
          <Rate>J_IP3_PHGFP</Rate>
          <Initial>IP3_PHGFP_Cyt_init</Initial>
        </OdeEquation>
        <OdeEquation Name='IP3X_Cytosol'>
          <Rate> - J_IP3_uncaging</Rate>
          <Initial>IP3X_Cytosol_init</Initial>
        </OdeEquation>
        <OdeEquation Name='IP3_Cyt'>
          <Rate>((RatePIP2_PH_hyd * Kflux_PM_Cytosol * KMOLE) + J_IP3_uncaging - Rate_IP3deg - J_IP3_PHGFP)</Rate>
          <Initial>IP3_Cyt_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PIP2_PM'>
          <Rate> - J_PIP2_PH</Rate>
          <Initial>PIP2_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='DAG_PM'>
          <Rate>RatePIP2_PH_hyd</Rate>
          <Initial>DAG_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PLC_act_PM'>
          <Rate>RatePLCact</Rate>
          <Initial>PLC_act_PM_init</Initial>
        </OdeEquation>
      </CompartmentSubDomain>
      <Version FromVersionable='true' Name='Average Exp Params - fast off'></Version>
    </MathDescription>
    <Simulation Annotation='' Name='First Try'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='KfPLCact'>0.0</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>4617.4</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='hv_Cytosol_init'>1.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='hv_Cytosol'>1.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='stim_PM_init'>0.0</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>3.6923</Constant>
        <Constant Name='tau0'>0.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='stimdecay'>6.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='intensity'>100000.0</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='stim_PM'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='krPLCact'>10.0</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>1.01446</Constant>
        <Constant Name='_R_'>8314.0</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='First Try'></Version>
    </Simulation>
    <Simulation Annotation='' Name='3X PH-GFP'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='KfPLCact'>0.0</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>(4617.4 * 3.0)</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='hv_Cytosol_init'>1.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='hv_Cytosol'>1.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='stim_PM_init'>0.0</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>(3.6923 * 3.0)</Constant>
        <Constant Name='tau0'>0.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='stimdecay'>6.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='intensity'>100000.0</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='stim_PM'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='krPLCact'>10.0</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>(2.30769 * 3.0)</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>1.01446</Constant>
        <Constant Name='_R_'>8314.0</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='3X PH-GFP'></Version>
    </Simulation>
    <Simulation Annotation='' Name='0.3X PH-GFP'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='KfPLCact'>0.0</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>(4617.4 * 0.3)</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='hv_Cytosol_init'>1.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='hv_Cytosol'>1.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='stim_PM_init'>0.0</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>(3.6923 * 0.3)</Constant>
        <Constant Name='tau0'>0.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='stimdecay'>6.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='intensity'>100000.0</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='stim_PM'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='krPLCact'>10.0</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>(2.30769 * 0.3)</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>1.01446</Constant>
        <Constant Name='_R_'>8314.0</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='0.3X PH-GFP'></Version>
    </Simulation>
    <Simulation Annotation='' Name='SS check - 0 IP3X_Cyt'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='KfPLCact'>0.0</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>4617.4</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='hv_Cytosol_init'>1.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='hv_Cytosol'>1.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='stim_PM_init'>0.0</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>3.6923</Constant>
        <Constant Name='tau0'>0.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='stimdecay'>6.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='kIP3deg'>0.16</Constant>
        <Constant Name='intensity'>100000.0</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='stim_PM'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='krPLCact'>10.0</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='_R_'>8314.0</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='SS check - 0 IP3X_Cyt'></Version>
    </Simulation>
    <Version FromVersionable='true' Name='uncaging'>(copied from Average Exp Params - Comp) (copied from SS for Exp params) (copied from steady state compartment) </Version>
  </SimulationSpec>
  <SimulationSpec Annotation='(copied from uncaging) (copied from Average Exp Params - Comp) (copied from SS for Exp params) (copied from steady state compartment) ' Name='Compartmental Sim'>
    <Geometry Dimension='0' Annotation='' Name='steady state compartment'>
      <Extent X='10.0' Y='10.0' Z='10.0' />
      <Origin X='0.0' Y='0.0' Z='0.0' />
      <SubVolume Handle='0' Type='Compartmental' Name='Compartment' />
      <Version FromVersionable='true' Name='steady state compartment'></Version>
    </Geometry>
    <GeometryContext>
      <FeatureMapping Resolved='false' Feature='Cytosol' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <FeatureMapping Resolved='false' Feature='Nucleus' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <FeatureMapping Resolved='false' Feature='Extraclellular' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <MembraneMapping Membrane='NM' SurfaceToVolumeRatio='1.0' SpecificCapacitance='0.01' InitialVoltage='0.0' VolumeFraction='0.1' CalculateVoltage='false' />
      <MembraneMapping Membrane='PM' SurfaceToVolumeRatio='0.263' SpecificCapacitance='0.01' InitialVoltage='0.0' VolumeFraction='0.8' CalculateVoltage='false' />
    </GeometryContext>
    <ReactionContext>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PH_GFP_Cyt' EnableDiffusion='true'>
        <Initial>5.46296</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='IP3_PHGFP_Cyt' EnableDiffusion='true'>
        <Initial>0.437037</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='hv_Cytosol' EnableDiffusion='true'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='IP3X_Cytosol' EnableDiffusion='true'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='IP3_Cyt' EnableDiffusion='true'>
        <Initial>0.16</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP2_PHGFP_PM' EnableDiffusion='false'>
        <Initial>2928.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PI_PM' EnableDiffusion='false'>
        <Initial>142857.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='stim_PM' EnableDiffusion='false'>
        <Initial>1.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP2_PM' EnableDiffusion='false'>
        <Initial>1072.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP_PM' EnableDiffusion='false'>
        <Initial>2857.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='DAG_PM' EnableDiffusion='false'>
        <Initial>2000.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PLC_PM' EnableDiffusion='false'>
        <Initial>100.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PLC_act_PM' EnableDiffusion='false'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3deg' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3-PHGFP' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_PH' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2Syn' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIPSyn' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_hyd' />
      <ReactionSpec ReactionMapping='excluded' ReactionStepRef='IP3_uncaging' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PLCact' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_PH_hyd' />
    </ReactionContext>
    <MathDescription Annotation='' Name='Compartmental Sim'>
      <Constant Name='KdPIP2PH'>2.0</Constant>
      <Constant Name='kBasalSynPIP'>0.0015</Constant>
      <Constant Name='PLC_PM_init'>100.0</Constant>
      <Constant Name='IP3_Cyt_init'>0.16</Constant>
      <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
      <Constant Name='hv_Cytosol_init'>0.0</Constant>
      <Constant Name='_F_'>96480.0</Constant>
      <Constant Name='PIP2syndecay'>10.0</Constant>
      <Constant Name='_R_'>8314.0</Constant>
      <Constant Name='stim_PM'>1.0</Constant>
      <Constant Name='PIP_basal'>2857.0</Constant>
      <Constant Name='PIPsyndecay'>10.0</Constant>
      <Constant Name='IP3_PHGFP_Cyt_init'>0.437037</Constant>
      <Constant Name='IP3X_Cytosol'>0.0</Constant>
      <Constant Name='kStimSynPIP'>0.01</Constant>
      <Constant Name='DAG_PM_init'>2000.0</Constant>
      <Constant Name='PI_PM_init'>142857.0</Constant>
      <Constant Name='k_PIP2hyd'>1.188</Constant>
      <Constant Name='PH_GFP_Cyt_init'>5.46296</Constant>
      <Constant Name='hv_Cytosol'>0.0</Constant>
      <Constant Name='SurfToVol_PM'>0.263</Constant>
      <Constant Name='kIP3deg'>0.16</Constant>
      <Constant Name='IP3_basal'>0.16</Constant>
      <Constant Name='PIP_PM_init'>2857.0</Constant>
      <Constant Name='PIP2_PM_init'>1072.0</Constant>
      <Constant Name='VolFract_Nucleus'>0.1</Constant>
      <Constant Name='KdIP3PH'>2.0</Constant>
      <Constant Name='stimdecay'>6.0</Constant>
      <Constant Name='kf_PIP2PH'>200.0</Constant>
      <Constant Name='PLC_act_PM_init'>0.0</Constant>
      <Constant Name='VolFract_Cytosol'>0.8</Constant>
      <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
      <Constant Name='kStimSynPIP2'>0.01</Constant>
      <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
      <Constant Name='krPLCact'>10.0</Constant>
      <Constant Name='tau0'>0.05</Constant>
      <Constant Name='SurfToVol_NM'>1.0</Constant>
      <Constant Name='tauPIPsyn'>0.05</Constant>
      <Constant Name='stim_PM_init'>1.0</Constant>
      <Constant Name='PIP2_PHGFP_PM_init'>2928.0</Constant>
      <Constant Name='PIP2_basal'>1072.0</Constant>
      <Constant Name='_T_'>300.0</Constant>
      <Constant Name='kf_IP3PH'>100.0</Constant>
      <Constant Name='kBasalSynPIP2'>0.045</Constant>
      <Constant Name='KfPLCact'>1000.0</Constant>
      <Constant Name='k_PIP2PHhyd'>50.0</Constant>
      <Constant Name='tauPIP2syn'>0.05</Constant>
      <VolumeVariable Name='IP3_PHGFP_Cyt' />
      <VolumeVariable Name='PLC_act_PM' />
      <VolumeVariable Name='PIP_PM' />
      <VolumeVariable Name='PI_PM' />
      <VolumeVariable Name='DAG_PM' />
      <VolumeVariable Name='PIP2_PM' />
      <VolumeVariable Name='IP3_Cyt' />
      <Function Name='K_PH_GFP_Cyt_total'>( - (DAG_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP2_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PI_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PH_GFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol) + (IP3_PHGFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol))</Function>
      <Function Name='PH_GFP_Cyt'>(((DAG_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PI_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + K_PH_GFP_Cyt_total - (IP3_PHGFP_Cyt * (1.0 - VolFract_Nucleus) * VolFract_Cytosol)) / ((1.0 - VolFract_Nucleus) * VolFract_Cytosol))</Function>
      <Function Name='kr_PIP2PH'>(kf_PIP2PH * KdPIP2PH)</Function>
      <Function Name='K_PIP2_PHGFP_PM_total'>((DAG_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PHGFP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PI_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='PIP2_PHGFP_PM'>(( - (DAG_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP2_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + K_PIP2_PHGFP_PM_total - (PI_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='J_PIP2_PH'>(((kf_PIP2PH * PH_GFP_Cyt) * PIP2_PM) - (kr_PIP2PH * PIP2_PHGFP_PM))</Function>
      <Function Name='signal'>((t &amp;gt; tau0) * exp( - ((t - tau0) / stimdecay)))</Function>
      <Function Name='Rate_PIP2SynStim'>(kStimSynPIP2 * exp( - ((t - tauPIP2syn) / PIP2syndecay)) * (t &amp;gt; tauPIP2syn))</Function>
      <Function Name='K_PLC_PM_total'>((PLC_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PLC_act_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='PLC_PM'>((K_PLC_PM_total - (PLC_act_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='RatePLCact'>((KfPLCact * (PLC_PM * stim_PM * signal)) - (krPLCact * PLC_act_PM))</Function>
      <Function Name='Ratebasal_PIPsyn'>((kBasalSynPIP * 0.581 * ( - 1.0 + exp(((PIP_basal - PIP_PM) / PIP_basal)))) * (PIP_PM &amp;lt; PIP_basal))</Function>
      <Function Name='Ratestim_PIPsyn'>(kStimSynPIP * exp( - ((t - tauPIPsyn) / PIPsyndecay)) * (t &amp;gt; tauPIPsyn))</Function>
      <Function Name='Rate_PIPSyn'>((Ratebasal_PIPsyn + Ratestim_PIPsyn) * PI_PM)</Function>
      <Function Name='Rate_PIP2_hyd'>(k_PIP2hyd * (PIP2_PM * PLC_act_PM))</Function>
      <Function Name='Rate_PIP2Synbasal'>((kBasalSynPIP2 * 0.581 * ( - 1.0 + exp(((PIP2_basal - PIP2_PM) / PIP2_basal)))) * (PIP2_PM &amp;lt; PIP2_basal))</Function>
      <Function Name='Rate_PIP2Syn'>((Rate_PIP2Synbasal + Rate_PIP2SynStim) * PIP_PM)</Function>
      <Function Name='Kflux_NM_Nucleus'>SurfToVol_NM</Function>
      <Function Name='kr_IP3PH'>(kf_IP3PH * KdIP3PH)</Function>
      <Function Name='J_IP3_PHGFP'>(((kf_IP3PH * IP3_Cyt) * PH_GFP_Cyt) - (kr_IP3PH * IP3_PHGFP_Cyt))</Function>
      <Function Name='Kflux_NM_Cytosol'>(SurfToVol_NM * VolFract_Nucleus / (1.0 - VolFract_Nucleus))</Function>
      <Function Name='Kflux_PM_Cytosol'>(SurfToVol_PM / (1.0 - VolFract_Nucleus))</Function>
      <Function Name='Voltage_Membrane0'>0.0</Function>
      <Function Name='Rate_IP3deg'>(kIP3deg * (IP3_Cyt - IP3_basal))</Function>
      <Function Name='Kflux_PM_Extraclellular'>(SurfToVol_PM * VolFract_Cytosol / (1.0 - VolFract_Cytosol))</Function>
      <Function Name='RatePIP2_PH_hyd'>(k_PIP2PHhyd * PLC_act_PM * PIP2_PHGFP_PM)</Function>
      <CompartmentSubDomain Name='Compartment'>
        <BoundaryType Type='Value' Boundary='Xm' />
        <BoundaryType Type='Value' Boundary='Xp' />
        <BoundaryType Type='Value' Boundary='Ym' />
        <BoundaryType Type='Value' Boundary='Yp' />
        <BoundaryType Type='Value' Boundary='Zm' />
        <BoundaryType Type='Value' Boundary='Zp' />
        <OdeEquation Name='IP3_PHGFP_Cyt'>
          <Rate>J_IP3_PHGFP</Rate>
          <Initial>IP3_PHGFP_Cyt_init</Initial>
        </OdeEquation>
        <OdeEquation Name='IP3_Cyt'>
          <Rate>((RatePIP2_PH_hyd * Kflux_PM_Cytosol * KMOLE) + (Rate_PIP2_hyd * Kflux_PM_Cytosol * KMOLE) - Rate_IP3deg - J_IP3_PHGFP)</Rate>
          <Initial>IP3_Cyt_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PI_PM'>
          <Rate> - Rate_PIPSyn</Rate>
          <Initial>PI_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PIP2_PM'>
          <Rate>( - Rate_PIP2_hyd - J_PIP2_PH + Rate_PIP2Syn)</Rate>
          <Initial>PIP2_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PIP_PM'>
          <Rate>( - Rate_PIP2Syn + Rate_PIPSyn)</Rate>
          <Initial>PIP_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='DAG_PM'>
          <Rate>(Rate_PIP2_hyd + RatePIP2_PH_hyd)</Rate>
          <Initial>DAG_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PLC_act_PM'>
          <Rate>RatePLCact</Rate>
          <Initial>PLC_act_PM_init</Initial>
        </OdeEquation>
      </CompartmentSubDomain>
      <Version FromVersionable='true' Name='Compartmental Sim'></Version>
    </MathDescription>
    <Simulation Annotation='S:V=.5&amp;#10;optimized rates&amp;#10;' Name='no PHGFP,  S:V=.5, slow I deg, fast stim syn &amp;amp; hyd opt'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='1.0E-4' />
        <ErrorTolerance Relative='1.0E-11' Absolut='1.0E-11' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='KdIP3PH'>2.0</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>0.0</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>0.0</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>0.0</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='no PHGFP,  S:V=.5, slow I deg, fast stim syn &amp;amp; hyd opt'>S:V=.5&amp;#10;optimized rates&amp;#10;</Version>
    </Simulation>
    <Simulation Annotation='S:V=.5&amp;#10;optimized rates&amp;#10;' Name='PHGFP, KdPHIP3=0.1, S:V=.5, slow I deg, fast stim syn &amp;amp; hyd opt'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='1.0E-4' />
        <ErrorTolerance Relative='1.0E-11' Absolut='1.0E-11' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>3.6923</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>4617.4</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='PHGFP, KdPHIP3=0.1, S:V=.5, slow I deg, fast stim syn &amp;amp; hyd opt'>S:V=.5&amp;#10;optimized rates&amp;#10;</Version>
    </Simulation>
    <Simulation Annotation='S:V=.5&amp;#10;optimized rates&amp;#10;' Name='KdPHIP3=0.1, S:V=.5, slow I deg, fast stim syn &amp;amp; hyd opt, 3X PH-GFP'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='1.0E-4' />
        <ErrorTolerance Relative='1.0E-11' Absolut='1.0E-11' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>(3.6923 * 3.0)</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>(2.30769 * 3.0)</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>(4617.4 * 3.0)</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='KdPHIP3=0.1, S:V=.5, slow I deg, fast stim syn &amp;amp; hyd opt, 3X PH-GFP'>S:V=.5&amp;#10;optimized rates&amp;#10;</Version>
    </Simulation>
    <Simulation Annotation='S:V=.5&amp;#10;optimized rates&amp;#10;' Name='KdPHIP3=0.1, S:V=.5, slow I deg, fast stim syn &amp;amp; hyd opt, 0.3X PH-GFP'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='1.0E-4' />
        <ErrorTolerance Relative='1.0E-11' Absolut='1.0E-11' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>(3.6923 * 0.3)</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>(2.30769 * 0.3)</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>(4617.4 * 0.3)</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='KdPHIP3=0.1, S:V=.5, slow I deg, fast stim syn &amp;amp; hyd opt, 0.3X PH-GFP'>S:V=.5&amp;#10;optimized rates&amp;#10;</Version>
    </Simulation>
    <Simulation Annotation='S:V=.5&amp;#10;optimized rates&amp;#10;' Name='copy of PHGFP, KdPHIP3=0.1, S:V=.5, slow I deg, fast stim syn &amp;amp; hyd opt'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='1.0E-4' />
        <ErrorTolerance Relative='1.0E-11' Absolut='1.0E-11' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>3.6923</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='kStimSynPIP2'>0.0</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>4617.4</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='kStimSynPIP'>0.0</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='copy of PHGFP, KdPHIP3=0.1, S:V=.5, slow I deg, fast stim syn &amp;amp; hyd opt'>S:V=.5&amp;#10;optimized rates&amp;#10;</Version>
    </Simulation>
    <Version FromVersionable='true' Name='Compartmental Sim'>(copied from uncaging) (copied from Average Exp Params - Comp) (copied from SS for Exp params) (copied from steady state compartment) </Version>
  </SimulationSpec>
  <SimulationSpec Annotation='(copied from Compartmental Sim) (copied from uncaging) (copied from Average Exp Params - Comp) (copied from SS for Exp params) (copied from steady state compartment) ' Name='Comp Fixed IP3'>
    <Geometry Dimension='0' Annotation='' Name='steady state compartment'>
      <Extent X='10.0' Y='10.0' Z='10.0' />
      <Origin X='0.0' Y='0.0' Z='0.0' />
      <SubVolume Handle='0' Type='Compartmental' Name='Compartment' />
      <Version FromVersionable='true' Name='steady state compartment'></Version>
    </Geometry>
    <GeometryContext>
      <FeatureMapping Resolved='false' Feature='Cytosol' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <FeatureMapping Resolved='false' Feature='Nucleus' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <FeatureMapping Resolved='false' Feature='Extraclellular' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <MembraneMapping Membrane='NM' SurfaceToVolumeRatio='1.0' SpecificCapacitance='0.01' InitialVoltage='0.0' VolumeFraction='0.1' CalculateVoltage='false' />
      <MembraneMapping Membrane='PM' SurfaceToVolumeRatio='0.5' SpecificCapacitance='0.01' InitialVoltage='0.0' VolumeFraction='0.8' CalculateVoltage='false' />
    </GeometryContext>
    <ReactionContext>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PH_GFP_Cyt' EnableDiffusion='true'>
        <Initial>2.30769</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='IP3_PHGFP_Cyt' EnableDiffusion='true'>
        <Initial>3.6923</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='hv_Cytosol' EnableDiffusion='true'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='IP3X_Cytosol' EnableDiffusion='true'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='IP3_Cyt' EnableDiffusion='true'>
        <Initial>0.16</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP2_PHGFP_PM' EnableDiffusion='false'>
        <Initial>4617.4</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PI_PM' EnableDiffusion='false'>
        <Initial>142857.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='stim_PM' EnableDiffusion='false'>
        <Initial>1.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP2_PM' EnableDiffusion='false'>
        <Initial>4000.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP_PM' EnableDiffusion='false'>
        <Initial>2857.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='DAG_PM' EnableDiffusion='false'>
        <Initial>2000.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PLC_PM' EnableDiffusion='false'>
        <Initial>100.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PLC_act_PM' EnableDiffusion='false'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3deg' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3-PHGFP' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_PH' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2Syn' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIPSyn' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_hyd' />
      <ReactionSpec ReactionMapping='excluded' ReactionStepRef='IP3_uncaging' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PLCact' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_PH_hyd' />
    </ReactionContext>
    <MathDescription Annotation='' Name='Comp Fixed IP3'>
      <Constant Name='KdPIP2PH'>2.0</Constant>
      <Constant Name='kBasalSynPIP'>0.0015</Constant>
      <Constant Name='PLC_PM_init'>100.0</Constant>
      <Constant Name='IP3_Cyt_init'>0.16</Constant>
      <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
      <Constant Name='hv_Cytosol_init'>0.0</Constant>
      <Constant Name='_F_'>96480.0</Constant>
      <Constant Name='PIP2syndecay'>10.0</Constant>
      <Constant Name='_R_'>8314.0</Constant>
      <Constant Name='stim_PM'>1.0</Constant>
      <Constant Name='PIP_basal'>2857.0</Constant>
      <Constant Name='PIPsyndecay'>10.0</Constant>
      <Constant Name='IP3_PHGFP_Cyt_init'>3.6923</Constant>
      <Constant Name='IP3X_Cytosol'>0.0</Constant>
      <Constant Name='kStimSynPIP'>0.01</Constant>
      <Constant Name='DAG_PM_init'>2000.0</Constant>
      <Constant Name='PI_PM_init'>142857.0</Constant>
      <Constant Name='k_PIP2hyd'>1.188</Constant>
      <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
      <Constant Name='hv_Cytosol'>0.0</Constant>
      <Constant Name='SurfToVol_PM'>0.5</Constant>
      <Constant Name='kIP3deg'>0.16</Constant>
      <Constant Name='IP3_basal'>0.16</Constant>
      <Constant Name='PIP_PM_init'>2857.0</Constant>
      <Constant Name='PIP2_PM_init'>4000.0</Constant>
      <Constant Name='VolFract_Nucleus'>0.1</Constant>
      <Constant Name='KdIP3PH'>2.0</Constant>
      <Constant Name='stimdecay'>6.0</Constant>
      <Constant Name='kf_PIP2PH'>200.0</Constant>
      <Constant Name='PLC_act_PM_init'>0.0</Constant>
      <Constant Name='VolFract_Cytosol'>0.8</Constant>
      <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
      <Constant Name='kStimSynPIP2'>0.01</Constant>
      <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
      <Constant Name='krPLCact'>10.0</Constant>
      <Constant Name='tau0'>0.05</Constant>
      <Constant Name='SurfToVol_NM'>1.0</Constant>
      <Constant Name='tauPIPsyn'>0.05</Constant>
      <Constant Name='stim_PM_init'>1.0</Constant>
      <Constant Name='PIP2_PHGFP_PM_init'>4617.4</Constant>
      <Constant Name='PIP2_basal'>1072.0</Constant>
      <Constant Name='_T_'>300.0</Constant>
      <Constant Name='kf_IP3PH'>100.0</Constant>
      <Constant Name='kBasalSynPIP2'>0.045</Constant>
      <Constant Name='KfPLCact'>1000.0</Constant>
      <Constant Name='IP3_Cyt'>0.16</Constant>
      <Constant Name='k_PIP2PHhyd'>50.0</Constant>
      <Constant Name='tauPIP2syn'>0.05</Constant>
      <VolumeVariable Name='IP3_PHGFP_Cyt' />
      <VolumeVariable Name='PLC_act_PM' />
      <VolumeVariable Name='PIP_PM' />
      <VolumeVariable Name='PI_PM' />
      <VolumeVariable Name='DAG_PM' />
      <VolumeVariable Name='PIP2_PM' />
      <Function Name='K_PH_GFP_Cyt_total'>( - (DAG_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP2_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PI_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PH_GFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol) + (IP3_PHGFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol))</Function>
      <Function Name='PH_GFP_Cyt'>(((DAG_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PI_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + K_PH_GFP_Cyt_total - (IP3_PHGFP_Cyt * (1.0 - VolFract_Nucleus) * VolFract_Cytosol)) / ((1.0 - VolFract_Nucleus) * VolFract_Cytosol))</Function>
      <Function Name='kr_PIP2PH'>(kf_PIP2PH * KdPIP2PH)</Function>
      <Function Name='K_PIP2_PHGFP_PM_total'>((DAG_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PIP2_PHGFP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PI_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='PIP2_PHGFP_PM'>(( - (DAG_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) - (PIP2_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + K_PIP2_PHGFP_PM_total - (PI_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='J_PIP2_PH'>(((kf_PIP2PH * PH_GFP_Cyt) * PIP2_PM) - (kr_PIP2PH * PIP2_PHGFP_PM))</Function>
      <Function Name='signal'>((t &amp;gt; tau0) * exp( - ((t - tau0) / stimdecay)))</Function>
      <Function Name='Rate_PIP2SynStim'>(kStimSynPIP2 * exp( - ((t - tauPIP2syn) / PIP2syndecay)) * (t &amp;gt; tauPIP2syn))</Function>
      <Function Name='K_PLC_PM_total'>((PLC_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PLC_act_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='PLC_PM'>((K_PLC_PM_total - (PLC_act_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='RatePLCact'>((KfPLCact * (PLC_PM * stim_PM * signal)) - (krPLCact * PLC_act_PM))</Function>
      <Function Name='Ratebasal_PIPsyn'>((kBasalSynPIP * 0.581 * ( - 1.0 + exp(((PIP_basal - PIP_PM) / PIP_basal)))) * (PIP_PM &amp;lt; PIP_basal))</Function>
      <Function Name='Ratestim_PIPsyn'>(kStimSynPIP * exp( - ((t - tauPIPsyn) / PIPsyndecay)) * (t &amp;gt; tauPIPsyn))</Function>
      <Function Name='Rate_PIPSyn'>((Ratebasal_PIPsyn + Ratestim_PIPsyn) * PI_PM)</Function>
      <Function Name='Rate_PIP2_hyd'>(k_PIP2hyd * (PIP2_PM * PLC_act_PM))</Function>
      <Function Name='Rate_PIP2Synbasal'>((kBasalSynPIP2 * 0.581 * ( - 1.0 + exp(((PIP2_basal - PIP2_PM) / PIP2_basal)))) * (PIP2_PM &amp;lt; PIP2_basal))</Function>
      <Function Name='Rate_PIP2Syn'>((Rate_PIP2Synbasal + Rate_PIP2SynStim) * PIP_PM)</Function>
      <Function Name='Kflux_NM_Nucleus'>SurfToVol_NM</Function>
      <Function Name='kr_IP3PH'>(kf_IP3PH * KdIP3PH)</Function>
      <Function Name='J_IP3_PHGFP'>(((kf_IP3PH * IP3_Cyt) * PH_GFP_Cyt) - (kr_IP3PH * IP3_PHGFP_Cyt))</Function>
      <Function Name='Kflux_NM_Cytosol'>(SurfToVol_NM * VolFract_Nucleus / (1.0 - VolFract_Nucleus))</Function>
      <Function Name='Kflux_PM_Cytosol'>(SurfToVol_PM / (1.0 - VolFract_Nucleus))</Function>
      <Function Name='Voltage_Membrane0'>0.0</Function>
      <Function Name='Rate_IP3deg'>(kIP3deg * (IP3_Cyt - IP3_basal))</Function>
      <Function Name='Kflux_PM_Extraclellular'>(SurfToVol_PM * VolFract_Cytosol / (1.0 - VolFract_Cytosol))</Function>
      <Function Name='RatePIP2_PH_hyd'>(k_PIP2PHhyd * PLC_act_PM * PIP2_PHGFP_PM)</Function>
      <CompartmentSubDomain Name='Compartment'>
        <BoundaryType Type='Value' Boundary='Xm' />
        <BoundaryType Type='Value' Boundary='Xp' />
        <BoundaryType Type='Value' Boundary='Ym' />
        <BoundaryType Type='Value' Boundary='Yp' />
        <BoundaryType Type='Value' Boundary='Zm' />
        <BoundaryType Type='Value' Boundary='Zp' />
        <OdeEquation Name='IP3_PHGFP_Cyt'>
          <Rate>J_IP3_PHGFP</Rate>
          <Initial>IP3_PHGFP_Cyt_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PI_PM'>
          <Rate> - Rate_PIPSyn</Rate>
          <Initial>PI_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PIP2_PM'>
          <Rate>( - Rate_PIP2_hyd - J_PIP2_PH + Rate_PIP2Syn)</Rate>
          <Initial>PIP2_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PIP_PM'>
          <Rate>( - Rate_PIP2Syn + Rate_PIPSyn)</Rate>
          <Initial>PIP_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='DAG_PM'>
          <Rate>(Rate_PIP2_hyd + RatePIP2_PH_hyd)</Rate>
          <Initial>DAG_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PLC_act_PM'>
          <Rate>RatePLCact</Rate>
          <Initial>PLC_act_PM_init</Initial>
        </OdeEquation>
      </CompartmentSubDomain>
      <Version FromVersionable='true' Name='Comp Fixed IP3'></Version>
    </MathDescription>
    <Simulation Annotation='' Name='Fixed IP3'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>3.6923</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='IP3_Cyt'>0.16</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>4617.4</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='Fixed IP3'></Version>
    </Simulation>
    <Simulation Annotation='' Name='Fixed IP3, 3x PH-GFP'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='PH_GFP_Cyt_init'>(2.30769 * 3.0)</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>(3.6923 * 3.0)</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='IP3_Cyt'>0.16</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>(4617.4 * 3.0)</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='Fixed IP3, 3x PH-GFP'></Version>
    </Simulation>
    <Simulation Annotation='' Name='Fixed IP3, 0.3x PH-GFP'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='PH_GFP_Cyt_init'>(2.30769 * 0.3)</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>(3.6923 * 0.3)</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
        <Constant Name='KdPIP2PH'>2.0</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='IP3_Cyt'>0.16</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>(4617.4 * 0.3)</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='Fixed IP3, 0.3x PH-GFP'></Version>
    </Simulation>
    <Simulation Annotation='' Name='Fixed IP3 Increase Affinity for PIP2'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.1</Constant>
        <Constant Name='KfPLCact'>5.0E-4</Constant>
        <Constant Name='hv_Cytosol_init'>0.0</Constant>
        <Constant Name='kIP3deg'>0.08</Constant>
        <Constant Name='PIP_basal'>2857.0</Constant>
        <Constant Name='hv_Cytosol'>0.0</Constant>
        <Constant Name='_T_'>300.0</Constant>
        <Constant Name='IP3_PHGFP_Cyt_init'>3.6923</Constant>
        <Constant Name='PLC_PM_init'>100.0</Constant>
        <Constant Name='IP3X_Cytosol'>0.0</Constant>
        <Constant Name='PIPsyndecay'>1.0</Constant>
        <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
        <Constant Name='PIP_PM_init'>2857.0</Constant>
        <Constant Name='VolFract_Cytosol'>0.8</Constant>
        <Constant Name='PIP2syndecay'>1.0</Constant>
        <Constant Name='KdPIP2PH'>0.1</Constant>
        <Constant Name='PIP2_PM_init'>4000.0</Constant>
        <Constant Name='SurfToVol_PM'>0.5</Constant>
        <Constant Name='tauPIP2syn'>0.05</Constant>
        <Constant Name='PI_PM_init'>142857.0</Constant>
        <Constant Name='kStimSynPIP'>0.019</Constant>
        <Constant Name='kBasalSynPIP'>0.0055</Constant>
        <Constant Name='k_PIP2PHhyd'>0.0</Constant>
        <Constant Name='stimdecay'>1.0</Constant>
        <Constant Name='kBasalSynPIP2'>0.048</Constant>
        <Constant Name='IP3_Cyt'>0.16</Constant>
        <Constant Name='PIP2_PHGFP_PM_init'>92307.6</Constant>
        <Constant Name='k_PIP2hyd'>2.4</Constant>
        <Constant Name='_R_'>8314.0</Constant>
        <Constant Name='kStimSynPIP2'>0.92</Constant>
      </MathOverrides>
      <Version FromVersionable='true' Name='Fixed IP3 Increase Affinity for PIP2'></Version>
    </Simulation>
    <Version FromVersionable='true' Name='Comp Fixed IP3'>(copied from Compartmental Sim) (copied from uncaging) (copied from Average Exp Params - Comp) (copied from SS for Exp params) (copied from steady state compartment) </Version>
  </SimulationSpec>
  <SimulationSpec Annotation='(copied from Comp Fixed IP3) (copied from Compartmental Sim) (copied from uncaging) (copied from Average Exp Params - Comp) (copied from SS for Exp params) (copied from steady state compartment) ' Name='Comp Fixed PIP2'>
    <Geometry Dimension='0' Annotation='' Name='steady state compartment'>
      <Extent X='10.0' Y='10.0' Z='10.0' />
      <Origin X='0.0' Y='0.0' Z='0.0' />
      <SubVolume Handle='0' Type='Compartmental' Name='Compartment' />
      <Version FromVersionable='true' Name='steady state compartment'></Version>
    </Geometry>
    <GeometryContext>
      <FeatureMapping Resolved='false' Feature='Cytosol' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <FeatureMapping Resolved='false' Feature='Nucleus' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <FeatureMapping Resolved='false' Feature='Extraclellular' SubVolume='Compartment'>
        <BoundariesTypes Yp='Value' Zp='Value' Xm='Value' Ym='Value' Xp='Value' Zm='Value' />
      </FeatureMapping>
      <MembraneMapping Membrane='NM' SurfaceToVolumeRatio='1.0' SpecificCapacitance='0.01' InitialVoltage='0.0' VolumeFraction='0.1' CalculateVoltage='false' />
      <MembraneMapping Membrane='PM' SurfaceToVolumeRatio='0.5' SpecificCapacitance='0.01' InitialVoltage='0.0' VolumeFraction='0.8' CalculateVoltage='false' />
    </GeometryContext>
    <ReactionContext>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PH_GFP_Cyt' EnableDiffusion='true'>
        <Initial>2.30769</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='IP3_PHGFP_Cyt' EnableDiffusion='true'>
        <Initial>3.6923</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='hv_Cytosol' EnableDiffusion='true'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='IP3X_Cytosol' EnableDiffusion='true'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='IP3_Cyt' EnableDiffusion='true'>
        <Initial>0.16</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP2_PHGFP_PM' EnableDiffusion='false'>
        <Initial>4617.4</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PI_PM' EnableDiffusion='false'>
        <Initial>142857.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='stim_PM' EnableDiffusion='false'>
        <Initial>1.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='true' LocalizedCompoundRef='PIP2_PM' EnableDiffusion='false'>
        <Initial>4000.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PIP_PM' EnableDiffusion='false'>
        <Initial>2857.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='DAG_PM' EnableDiffusion='false'>
        <Initial>2000.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PLC_PM' EnableDiffusion='false'>
        <Initial>100.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <LocalizedCompoundSpec ForceConstant='false' LocalizedCompoundRef='PLC_act_PM' EnableDiffusion='false'>
        <Initial>0.0</Initial>
        <Diffusion>0.0</Diffusion>
      </LocalizedCompoundSpec>
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3deg' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='IP3-PHGFP' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_PH' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2Syn' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIPSyn' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_hyd' />
      <ReactionSpec ReactionMapping='excluded' ReactionStepRef='IP3_uncaging' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PLCact' />
      <ReactionSpec ReactionMapping='included' ReactionStepRef='PIP2_PH_hyd' />
    </ReactionContext>
    <MathDescription Annotation='' Name='Comp Fixed PIP2'>
      <Constant Name='KdPIP2PH'>2.0</Constant>
      <Constant Name='kBasalSynPIP'>0.0015</Constant>
      <Constant Name='PLC_PM_init'>100.0</Constant>
      <Constant Name='IP3_Cyt_init'>0.16</Constant>
      <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
      <Constant Name='hv_Cytosol_init'>0.0</Constant>
      <Constant Name='_F_'>96480.0</Constant>
      <Constant Name='PIP2syndecay'>10.0</Constant>
      <Constant Name='_R_'>8314.0</Constant>
      <Constant Name='stim_PM'>1.0</Constant>
      <Constant Name='PIP_basal'>2857.0</Constant>
      <Constant Name='PIPsyndecay'>10.0</Constant>
      <Constant Name='IP3_PHGFP_Cyt_init'>3.6923</Constant>
      <Constant Name='IP3X_Cytosol'>0.0</Constant>
      <Constant Name='kStimSynPIP'>0.01</Constant>
      <Constant Name='DAG_PM_init'>2000.0</Constant>
      <Constant Name='PI_PM_init'>142857.0</Constant>
      <Constant Name='k_PIP2hyd'>1.188</Constant>
      <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
      <Constant Name='hv_Cytosol'>0.0</Constant>
      <Constant Name='SurfToVol_PM'>0.5</Constant>
      <Constant Name='kIP3deg'>0.16</Constant>
      <Constant Name='IP3_basal'>0.16</Constant>
      <Constant Name='PIP_PM_init'>2857.0</Constant>
      <Constant Name='PIP2_PM_init'>4000.0</Constant>
      <Constant Name='VolFract_Nucleus'>0.1</Constant>
      <Constant Name='KdIP3PH'>2.0</Constant>
      <Constant Name='stimdecay'>6.0</Constant>
      <Constant Name='kf_PIP2PH'>200.0</Constant>
      <Constant Name='PLC_act_PM_init'>0.0</Constant>
      <Constant Name='VolFract_Cytosol'>0.8</Constant>
      <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
      <Constant Name='kStimSynPIP2'>0.01</Constant>
      <Constant Name='KMOLE'>(1.0 / 602.0)</Constant>
      <Constant Name='krPLCact'>10.0</Constant>
      <Constant Name='tau0'>0.05</Constant>
      <Constant Name='SurfToVol_NM'>1.0</Constant>
      <Constant Name='tauPIPsyn'>0.05</Constant>
      <Constant Name='stim_PM_init'>1.0</Constant>
      <Constant Name='PIP2_PHGFP_PM_init'>4617.4</Constant>
      <Constant Name='PIP2_basal'>1072.0</Constant>
      <Constant Name='_T_'>300.0</Constant>
      <Constant Name='kf_IP3PH'>100.0</Constant>
      <Constant Name='kBasalSynPIP2'>0.045</Constant>
      <Constant Name='PIP2_PM'>4000.0</Constant>
      <Constant Name='KfPLCact'>1000.0</Constant>
      <Constant Name='k_PIP2PHhyd'>50.0</Constant>
      <Constant Name='tauPIP2syn'>0.05</Constant>
      <VolumeVariable Name='IP3_PHGFP_Cyt' />
      <VolumeVariable Name='PIP2_PHGFP_PM' />
      <VolumeVariable Name='PLC_act_PM' />
      <VolumeVariable Name='PIP_PM' />
      <VolumeVariable Name='PI_PM' />
      <VolumeVariable Name='DAG_PM' />
      <VolumeVariable Name='IP3_Cyt' />
      <Function Name='K_PH_GFP_Cyt_total'>((PIP2_PHGFP_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PH_GFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol) + (IP3_PHGFP_Cyt_init * (1.0 - VolFract_Nucleus) * VolFract_Cytosol))</Function>
      <Function Name='PH_GFP_Cyt'>(( - (PIP2_PHGFP_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE) + K_PH_GFP_Cyt_total - (IP3_PHGFP_Cyt * (1.0 - VolFract_Nucleus) * VolFract_Cytosol)) / ((1.0 - VolFract_Nucleus) * VolFract_Cytosol))</Function>
      <Function Name='kr_PIP2PH'>(kf_PIP2PH * KdPIP2PH)</Function>
      <Function Name='J_PIP2_PH'>(((kf_PIP2PH * PH_GFP_Cyt) * PIP2_PM) - (kr_PIP2PH * PIP2_PHGFP_PM))</Function>
      <Function Name='signal'>((t &amp;gt; tau0) * exp( - ((t - tau0) / stimdecay)))</Function>
      <Function Name='Rate_PIP2SynStim'>(kStimSynPIP2 * exp( - ((t - tauPIP2syn) / PIP2syndecay)) * (t &amp;gt; tauPIP2syn))</Function>
      <Function Name='K_PLC_PM_total'>((PLC_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE) + (PLC_act_PM_init * SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='PLC_PM'>((K_PLC_PM_total - (PLC_act_PM * SurfToVol_PM * VolFract_Cytosol * KMOLE)) / (SurfToVol_PM * VolFract_Cytosol * KMOLE))</Function>
      <Function Name='RatePLCact'>((KfPLCact * (PLC_PM * stim_PM * signal)) - (krPLCact * PLC_act_PM))</Function>
      <Function Name='Ratebasal_PIPsyn'>((kBasalSynPIP * 0.581 * ( - 1.0 + exp(((PIP_basal - PIP_PM) / PIP_basal)))) * (PIP_PM &amp;lt; PIP_basal))</Function>
      <Function Name='Ratestim_PIPsyn'>(kStimSynPIP * exp( - ((t - tauPIPsyn) / PIPsyndecay)) * (t &amp;gt; tauPIPsyn))</Function>
      <Function Name='Rate_PIPSyn'>((Ratebasal_PIPsyn + Ratestim_PIPsyn) * PI_PM)</Function>
      <Function Name='Rate_PIP2_hyd'>(k_PIP2hyd * (PIP2_PM * PLC_act_PM))</Function>
      <Function Name='Rate_PIP2Synbasal'>((kBasalSynPIP2 * 0.581 * ( - 1.0 + exp(((PIP2_basal - PIP2_PM) / PIP2_basal)))) * (PIP2_PM &amp;lt; PIP2_basal))</Function>
      <Function Name='Rate_PIP2Syn'>((Rate_PIP2Synbasal + Rate_PIP2SynStim) * PIP_PM)</Function>
      <Function Name='Kflux_NM_Nucleus'>SurfToVol_NM</Function>
      <Function Name='kr_IP3PH'>(kf_IP3PH * KdIP3PH)</Function>
      <Function Name='J_IP3_PHGFP'>(((kf_IP3PH * IP3_Cyt) * PH_GFP_Cyt) - (kr_IP3PH * IP3_PHGFP_Cyt))</Function>
      <Function Name='Kflux_NM_Cytosol'>(SurfToVol_NM * VolFract_Nucleus / (1.0 - VolFract_Nucleus))</Function>
      <Function Name='Kflux_PM_Cytosol'>(SurfToVol_PM / (1.0 - VolFract_Nucleus))</Function>
      <Function Name='Voltage_Membrane0'>0.0</Function>
      <Function Name='Rate_IP3deg'>(kIP3deg * (IP3_Cyt - IP3_basal))</Function>
      <Function Name='Kflux_PM_Extraclellular'>(SurfToVol_PM * VolFract_Cytosol / (1.0 - VolFract_Cytosol))</Function>
      <Function Name='RatePIP2_PH_hyd'>(k_PIP2PHhyd * PLC_act_PM * PIP2_PHGFP_PM)</Function>
      <CompartmentSubDomain Name='Compartment'>
        <BoundaryType Type='Value' Boundary='Xm' />
        <BoundaryType Type='Value' Boundary='Xp' />
        <BoundaryType Type='Value' Boundary='Ym' />
        <BoundaryType Type='Value' Boundary='Yp' />
        <BoundaryType Type='Value' Boundary='Zm' />
        <BoundaryType Type='Value' Boundary='Zp' />
        <OdeEquation Name='IP3_PHGFP_Cyt'>
          <Rate>J_IP3_PHGFP</Rate>
          <Initial>IP3_PHGFP_Cyt_init</Initial>
        </OdeEquation>
        <OdeEquation Name='IP3_Cyt'>
          <Rate>((RatePIP2_PH_hyd * Kflux_PM_Cytosol * KMOLE) + (Rate_PIP2_hyd * Kflux_PM_Cytosol * KMOLE) - Rate_IP3deg - J_IP3_PHGFP)</Rate>
          <Initial>IP3_Cyt_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PIP2_PHGFP_PM'>
          <Rate>(J_PIP2_PH - RatePIP2_PH_hyd)</Rate>
          <Initial>PIP2_PHGFP_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PI_PM'>
          <Rate> - Rate_PIPSyn</Rate>
          <Initial>PI_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PIP_PM'>
          <Rate>( - Rate_PIP2Syn + Rate_PIPSyn)</Rate>
          <Initial>PIP_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='DAG_PM'>
          <Rate>(Rate_PIP2_hyd + RatePIP2_PH_hyd)</Rate>
          <Initial>DAG_PM_init</Initial>
        </OdeEquation>
        <OdeEquation Name='PLC_act_PM'>
          <Rate>RatePLCact</Rate>
          <Initial>PLC_act_PM_init</Initial>
        </OdeEquation>
      </CompartmentSubDomain>
      <Version FromVersionable='true' Name='Comp Fixed PIP2'></Version>
    </MathDescription>
    <Simulation Annotation='' Name='Fixed PIP2'>
      <SolverTaskDescription TaskType='Unsteady' KeepAtMost='1000' Solver='LSODA (Variable Order, Variable Time Step)' KeepEvery='10'>
        <TimeBound StartTime='0.0' EndTime='220.0' />
        <TimeStep MaxTime='1.0' MinTime='1.0E-13' DefaultTime='0.0010' />
        <ErrorTolerance Relative='1.0E-9' Absolut='1.0E-9' />
      </SolverTaskDescription>
      <MathOverrides>
        <Constant Name='tau0'>0.05</Constant>
        <Constant Name='_F_'>96480.0</Constant>
        <Constant Name='tauPIPsyn'>0.05</Constant>
        <Constant Name='stim_PM'>1.0</Constant>
        <Constant Name='PIP2_basal'>4000.0</Constant>
        <Constant Name='kf_IP3PH'>10.0</Constant>
        <Constant Name='IP3_Cyt_init'>0.16</Constant>
        <Constant Name='IP3_basal'>0.16</Constant>
        <Constant Name='PH_GFP_Cyt_init'>2.30769</Constant>
        <Constant Name='K_milliVolts_per_Volt'>1000.0</Constant>
        <Constant Name='krPLCact'>0.1</Constant>
        <Constant Name='VolFract_Nucleus'>0.1</Constant>
        <Constant Name='stim_PM_init'>1.0</Constant>
        <Constant Name='SurfToVol_NM'>1.0</Constant>
        <Constant Name='PLC_act_PM_init'>0.0</Constant>
        <Constant Name='kf_PIP2PH'>0.12</Constant>
        <Constant Name='DAG_PM_init'>2000.0</Constant>
        <Constant Name='IP3X_Cytosol_init'>0.0</Constant>
        <Constant Name='KdIP3PH'>0.